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Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure

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Standard

Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure. / Strauss, Gitte Irene; Høgh, Peter; Møller, Kirsten; Knudsen, Karen Birgitte Moos; Hansen, Bent Adel; Larsen, Fin Stolze.

I: Hepatology, Bind 30, 31.12.1999, s. 1368-1373.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Strauss, GI, Høgh, P, Møller, K, Knudsen, KBM, Hansen, BA & Larsen, FS 1999, 'Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure', Hepatology, bind 30, s. 1368-1373.

APA

Strauss, G. I., Høgh, P., Møller, K., Knudsen, K. B. M., Hansen, B. A., & Larsen, F. S. (1999). Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure. Hepatology, 30, 1368-1373.

Vancouver

Strauss GI, Høgh P, Møller K, Knudsen KBM, Hansen BA, Larsen FS. Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure. Hepatology. 1999 dec 31;30:1368-1373.

Author

Strauss, Gitte Irene ; Høgh, Peter ; Møller, Kirsten ; Knudsen, Karen Birgitte Moos ; Hansen, Bent Adel ; Larsen, Fin Stolze. / Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure. I: Hepatology. 1999 ; Bind 30. s. 1368-1373.

Bibtex

@article{4f1ade998ae544cc809f6ef300d98fb8,
title = "Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure",
abstract = "Hyperventilation is frequently used to prevent or postpone the development of cerebral edema and intracranial hypertension in patients with fulminant hepatic failure (FHF). The influence of such therapy on regional cerebral blood flow (rCBF) remains, however, unknown. In this study the CBF-distribution pattern was determined within the first 12 hours after development of hepatic encephalopathy (HE) stage 4 before and during hyperventilation. Ten consecutive patients (median age 48 [range 33-57] years) with FHF and 9 healthy controls (median age 54 [24-58] years) had rCBF determined by single photon emission computed tomography (SPECT) using intravenous injection of 133Xenon. For determination of high resolution CBF pattern, the patients were also studied with 99mTc-hexa-methylpropyleneamine oxime (HMPAO) in the hyperventilation condition. There was no significant difference in the rCBF distribution pattern during normoventilation as compared with hyperventilation. The anterior to posterior (AP) ratio was significantly lower in patients as compared with healthy controls. After hepatic recovery and disappearance of HE, 3 patients had restored normal rCBF distribution pattern as compared with healthy controls. We conclude that in sedated patients with FHF, a relatively lower rCBF is found in the frontal regions and in the basal ganglia as compared with posterior regions. This rCBF-distribution pattern was not aggravated during hyperventilation. It is speculated that this change of rCBF in patients with FHF may render the frontal brain regions more susceptible to hypoxia. The relative frontal rCBF decrease was shown to be reversible with hepatic recovery and alleviation of HE.",
author = "Strauss, {Gitte Irene} and Peter H{\o}gh and Kirsten M{\o}ller and Knudsen, {Karen Birgitte Moos} and Hansen, {Bent Adel} and Larsen, {Fin Stolze}",
year = "1999",
month = "12",
day = "31",
language = "English",
volume = "30",
pages = "1368--1373",
journal = "Hepatology",
issn = "0270-9139",
publisher = "JohnWiley & Sons, Inc.",

}

RIS

TY - JOUR

T1 - Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure

AU - Strauss, Gitte Irene

AU - Høgh, Peter

AU - Møller, Kirsten

AU - Knudsen, Karen Birgitte Moos

AU - Hansen, Bent Adel

AU - Larsen, Fin Stolze

PY - 1999/12/31

Y1 - 1999/12/31

N2 - Hyperventilation is frequently used to prevent or postpone the development of cerebral edema and intracranial hypertension in patients with fulminant hepatic failure (FHF). The influence of such therapy on regional cerebral blood flow (rCBF) remains, however, unknown. In this study the CBF-distribution pattern was determined within the first 12 hours after development of hepatic encephalopathy (HE) stage 4 before and during hyperventilation. Ten consecutive patients (median age 48 [range 33-57] years) with FHF and 9 healthy controls (median age 54 [24-58] years) had rCBF determined by single photon emission computed tomography (SPECT) using intravenous injection of 133Xenon. For determination of high resolution CBF pattern, the patients were also studied with 99mTc-hexa-methylpropyleneamine oxime (HMPAO) in the hyperventilation condition. There was no significant difference in the rCBF distribution pattern during normoventilation as compared with hyperventilation. The anterior to posterior (AP) ratio was significantly lower in patients as compared with healthy controls. After hepatic recovery and disappearance of HE, 3 patients had restored normal rCBF distribution pattern as compared with healthy controls. We conclude that in sedated patients with FHF, a relatively lower rCBF is found in the frontal regions and in the basal ganglia as compared with posterior regions. This rCBF-distribution pattern was not aggravated during hyperventilation. It is speculated that this change of rCBF in patients with FHF may render the frontal brain regions more susceptible to hypoxia. The relative frontal rCBF decrease was shown to be reversible with hepatic recovery and alleviation of HE.

AB - Hyperventilation is frequently used to prevent or postpone the development of cerebral edema and intracranial hypertension in patients with fulminant hepatic failure (FHF). The influence of such therapy on regional cerebral blood flow (rCBF) remains, however, unknown. In this study the CBF-distribution pattern was determined within the first 12 hours after development of hepatic encephalopathy (HE) stage 4 before and during hyperventilation. Ten consecutive patients (median age 48 [range 33-57] years) with FHF and 9 healthy controls (median age 54 [24-58] years) had rCBF determined by single photon emission computed tomography (SPECT) using intravenous injection of 133Xenon. For determination of high resolution CBF pattern, the patients were also studied with 99mTc-hexa-methylpropyleneamine oxime (HMPAO) in the hyperventilation condition. There was no significant difference in the rCBF distribution pattern during normoventilation as compared with hyperventilation. The anterior to posterior (AP) ratio was significantly lower in patients as compared with healthy controls. After hepatic recovery and disappearance of HE, 3 patients had restored normal rCBF distribution pattern as compared with healthy controls. We conclude that in sedated patients with FHF, a relatively lower rCBF is found in the frontal regions and in the basal ganglia as compared with posterior regions. This rCBF-distribution pattern was not aggravated during hyperventilation. It is speculated that this change of rCBF in patients with FHF may render the frontal brain regions more susceptible to hypoxia. The relative frontal rCBF decrease was shown to be reversible with hepatic recovery and alleviation of HE.

M3 - Journal article

VL - 30

SP - 1368

EP - 1373

JO - Hepatology

JF - Hepatology

SN - 0270-9139

ER -

ID: 162947463