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Regional variations of cell surface carbohydrates in human oral stratified epithelium

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Standard

Regional variations of cell surface carbohydrates in human oral stratified epithelium. / Vedtofte, P; Dabelsteen, Erik; Hakomori, S; Young, W W.

I: Differentiation, Bind 25, Nr. 3, 1984, s. 221-8.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Harvard

Vedtofte, P, Dabelsteen, E, Hakomori, S & Young, WW 1984, 'Regional variations of cell surface carbohydrates in human oral stratified epithelium', Differentiation, bind 25, nr. 3, s. 221-8.

APA

Vedtofte, P., Dabelsteen, E., Hakomori, S., & Young, W. W. (1984). Regional variations of cell surface carbohydrates in human oral stratified epithelium. Differentiation, 25(3), 221-8.

Vancouver

Vedtofte P, Dabelsteen E, Hakomori S, Young WW. Regional variations of cell surface carbohydrates in human oral stratified epithelium. Differentiation. 1984;25(3):221-8.

Author

Vedtofte, P ; Dabelsteen, Erik ; Hakomori, S ; Young, W W. / Regional variations of cell surface carbohydrates in human oral stratified epithelium. I: Differentiation. 1984 ; Bind 25, Nr. 3. s. 221-8.

Bibtex

@article{1020d5ec9e64407c9e9f2107325fed3f,
title = "Regional variations of cell surface carbohydrates in human oral stratified epithelium",
abstract = "The distribution of blood group carbohydrate chains with antigen A, B, H type 2 chain (A and B precursor), and N-acetyllactosamine (H type 2 precursor) specificity was studied in human oral epithelium from different anatomical regions. These represented various epithelial differentiation patterns such as non-keratinized, parakeratinized, and orthokeratinized stratified squamous epithelium. The material included buccal and palatal epithelium from 20 persons with blood group A or O, gingival, and alveolar epithelium from 10 persons with blood group A or B, and buccal metaplastically keratinized epithelium from nine blood group A, two blood group B, and nine blood group O individuals. The blood group carbohydrate chains were examined in tissue sections by immunofluorescence microscopy. The A and B blood group antigens were detected by human blood group sera, and antigen H type 2 chains and N-acetyllactosamine by murine monoclonal antibodies. Each antigen showed a similar staining pattern in buccal and alveolar epithelium (non-keratinized) which differed considerably from that seen in palatal and gingival epithelium (ortho- and parakeratinized). The expression of blood group antigens A or B and the precursor antigen H type 2 chains in metaplastically keratinized buccal epithelium was found to differ significantly from that seen in normal non-keratinized buccal epithelium. The regional variations demonstrated in cell surface carbohydrates are suggested to reflect differences in tissue differentiation.",
keywords = "ABO Blood-Group System, Adolescent, Adult, Aged, Carbohydrate Metabolism, Carbohydrates, Cell Differentiation, Cell Membrane, Epithelium, Female, Fluorescent Antibody Technique, Humans, Keratins, Male, Middle Aged, Mouth Mucosa, Tissue Distribution",
author = "P Vedtofte and Erik Dabelsteen and S Hakomori and Young, {W W}",
year = "1984",
language = "English",
volume = "25",
pages = "221--8",
journal = "Differentiation",
issn = "0301-4681",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Regional variations of cell surface carbohydrates in human oral stratified epithelium

AU - Vedtofte, P

AU - Dabelsteen, Erik

AU - Hakomori, S

AU - Young, W W

PY - 1984

Y1 - 1984

N2 - The distribution of blood group carbohydrate chains with antigen A, B, H type 2 chain (A and B precursor), and N-acetyllactosamine (H type 2 precursor) specificity was studied in human oral epithelium from different anatomical regions. These represented various epithelial differentiation patterns such as non-keratinized, parakeratinized, and orthokeratinized stratified squamous epithelium. The material included buccal and palatal epithelium from 20 persons with blood group A or O, gingival, and alveolar epithelium from 10 persons with blood group A or B, and buccal metaplastically keratinized epithelium from nine blood group A, two blood group B, and nine blood group O individuals. The blood group carbohydrate chains were examined in tissue sections by immunofluorescence microscopy. The A and B blood group antigens were detected by human blood group sera, and antigen H type 2 chains and N-acetyllactosamine by murine monoclonal antibodies. Each antigen showed a similar staining pattern in buccal and alveolar epithelium (non-keratinized) which differed considerably from that seen in palatal and gingival epithelium (ortho- and parakeratinized). The expression of blood group antigens A or B and the precursor antigen H type 2 chains in metaplastically keratinized buccal epithelium was found to differ significantly from that seen in normal non-keratinized buccal epithelium. The regional variations demonstrated in cell surface carbohydrates are suggested to reflect differences in tissue differentiation.

AB - The distribution of blood group carbohydrate chains with antigen A, B, H type 2 chain (A and B precursor), and N-acetyllactosamine (H type 2 precursor) specificity was studied in human oral epithelium from different anatomical regions. These represented various epithelial differentiation patterns such as non-keratinized, parakeratinized, and orthokeratinized stratified squamous epithelium. The material included buccal and palatal epithelium from 20 persons with blood group A or O, gingival, and alveolar epithelium from 10 persons with blood group A or B, and buccal metaplastically keratinized epithelium from nine blood group A, two blood group B, and nine blood group O individuals. The blood group carbohydrate chains were examined in tissue sections by immunofluorescence microscopy. The A and B blood group antigens were detected by human blood group sera, and antigen H type 2 chains and N-acetyllactosamine by murine monoclonal antibodies. Each antigen showed a similar staining pattern in buccal and alveolar epithelium (non-keratinized) which differed considerably from that seen in palatal and gingival epithelium (ortho- and parakeratinized). The expression of blood group antigens A or B and the precursor antigen H type 2 chains in metaplastically keratinized buccal epithelium was found to differ significantly from that seen in normal non-keratinized buccal epithelium. The regional variations demonstrated in cell surface carbohydrates are suggested to reflect differences in tissue differentiation.

KW - ABO Blood-Group System

KW - Adolescent

KW - Adult

KW - Aged

KW - Carbohydrate Metabolism

KW - Carbohydrates

KW - Cell Differentiation

KW - Cell Membrane

KW - Epithelium

KW - Female

KW - Fluorescent Antibody Technique

KW - Humans

KW - Keratins

KW - Male

KW - Middle Aged

KW - Mouth Mucosa

KW - Tissue Distribution

M3 - Journal article

C2 - 6199247

VL - 25

SP - 221

EP - 228

JO - Differentiation

JF - Differentiation

SN - 0301-4681

IS - 3

ER -

ID: 119594533