Forskning ved Københavns Universitet - Københavns Universitet

Forside

Regulation and limitations to fatty acid oxidation during exercise

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Fatty acids (FA) as fuel for energy utilization during exercise originate from different sources: FA transported in the circulation either bound to albumin or as triacylglycerol (TG) carried by very low density lipoproteins (VLDL) and FA from lipolysis of muscle TG stores (IMTG). Despite a high rate of energy expenditure during high intensity exercise the total fatty acid oxidation is suppressed to below that observed during moderate intensity exercise. Although this has been known for many years, the mechanisms behind this phenomenon are still not fully elucidated. A failure of adipose tissue to deliver sufficient fatty acids to exercising muscle has been proposed, but evidence is emerging that factors within the muscle might be of more importance. The high rate of glycolysis during high intensity exercise might be the "driving force" via the increased production of acetyl CoA which in turn is trapped by carnitine. This will lead to less availability of free carnitine for fatty acid transport into mitochondria. This review summarizes our present view on how FA metabolism is regulated during exercise with a special focus on the limitations in FA oxidation in the transition from moderate to high intensity exercise in humans.
OriginalsprogEngelsk
TidsskriftJournal of Physiology
Vol/bind590
Udgave nummer5
Sider (fra-til)1059-1068
Antal sider10
ISSN0022-3751
DOI
StatusUdgivet - 2012

Bibliografisk note

CURIS 2012 5200 025

ID: 37588542