Forskning ved Københavns Universitet - Københavns Universitet

Forside

Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses. / Imsland, Freyja; McGowan, Kelly; Rubin, Carl-Johan; Henegar, Corneliu; Sundström, Elisabeth; Berglund, Jonas; Schwochow, Doreen; Gustafson, Ulla; Imsland, Páll; Lindblad-Toh, Kerstin; Lindgren, Gabriella; Mikko, Sofia; Millon, Lee; Wade, Claire; Schubert, Mikkel; Orlando, Ludovic Antoine Alexandre; Penedo, Maria Cecilia T.; Barsh, Gregory S.; Andersson, Leif.

I: Nature Genetics, Bind 48, Nr. 2, 2016, s. 152-158.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Imsland, F, McGowan, K, Rubin, C-J, Henegar, C, Sundström, E, Berglund, J, Schwochow, D, Gustafson, U, Imsland, P, Lindblad-Toh, K, Lindgren, G, Mikko, S, Millon, L, Wade, C, Schubert, M, Orlando, LAA, Penedo, MCT, Barsh, GS & Andersson, L 2016, 'Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses', Nature Genetics, bind 48, nr. 2, s. 152-158. https://doi.org/10.1038/ng.3475

APA

Imsland, F., McGowan, K., Rubin, C-J., Henegar, C., Sundström, E., Berglund, J., ... Andersson, L. (2016). Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses. Nature Genetics, 48(2), 152-158. https://doi.org/10.1038/ng.3475

Vancouver

Imsland F, McGowan K, Rubin C-J, Henegar C, Sundström E, Berglund J o.a. Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses. Nature Genetics. 2016;48(2):152-158. https://doi.org/10.1038/ng.3475

Author

Imsland, Freyja ; McGowan, Kelly ; Rubin, Carl-Johan ; Henegar, Corneliu ; Sundström, Elisabeth ; Berglund, Jonas ; Schwochow, Doreen ; Gustafson, Ulla ; Imsland, Páll ; Lindblad-Toh, Kerstin ; Lindgren, Gabriella ; Mikko, Sofia ; Millon, Lee ; Wade, Claire ; Schubert, Mikkel ; Orlando, Ludovic Antoine Alexandre ; Penedo, Maria Cecilia T. ; Barsh, Gregory S. ; Andersson, Leif. / Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses. I: Nature Genetics. 2016 ; Bind 48, Nr. 2. s. 152-158.

Bibtex

@article{fc34a6278fc14c139d296ae41982f92b,
title = "Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses",
abstract = "Dun is a wild-type coat color in horses characterized by pigment dilution with a striking pattern of dark areas termed primitive markings. Here we show that pigment dilution in Dun horses is due to radially asymmetric deposition of pigment in the growing hair caused by localized expression of the T-box 3 (TBX3) transcription factor in hair follicles, which in turn determines the distribution of hair follicle melanocytes. Most domestic horses are non-dun, a more intensely pigmented phenotype caused by regulatory mutations impairing TBX3 expression in the hair follicle, resulting in a more circumferential distribution of melanocytes and pigment granules in individual hairs. We identified two different alleles (non-dun1 and non-dun2) causing non-dun color. non-dun2 is a recently derived allele, whereas the Dun and non-dun1 alleles are found in ancient horse DNA, demonstrating that this polymorphism predates horse domestication. These findings uncover a new developmental role for T-box genes and new aspects of hair follicle biology and pigmentation.",
author = "Freyja Imsland and Kelly McGowan and Carl-Johan Rubin and Corneliu Henegar and Elisabeth Sundstr{\"o}m and Jonas Berglund and Doreen Schwochow and Ulla Gustafson and P{\'a}ll Imsland and Kerstin Lindblad-Toh and Gabriella Lindgren and Sofia Mikko and Lee Millon and Claire Wade and Mikkel Schubert and Orlando, {Ludovic Antoine Alexandre} and Penedo, {Maria Cecilia T.} and Barsh, {Gregory S.} and Leif Andersson",
year = "2016",
doi = "10.1038/ng.3475",
language = "English",
volume = "48",
pages = "152--158",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses

AU - Imsland, Freyja

AU - McGowan, Kelly

AU - Rubin, Carl-Johan

AU - Henegar, Corneliu

AU - Sundström, Elisabeth

AU - Berglund, Jonas

AU - Schwochow, Doreen

AU - Gustafson, Ulla

AU - Imsland, Páll

AU - Lindblad-Toh, Kerstin

AU - Lindgren, Gabriella

AU - Mikko, Sofia

AU - Millon, Lee

AU - Wade, Claire

AU - Schubert, Mikkel

AU - Orlando, Ludovic Antoine Alexandre

AU - Penedo, Maria Cecilia T.

AU - Barsh, Gregory S.

AU - Andersson, Leif

PY - 2016

Y1 - 2016

N2 - Dun is a wild-type coat color in horses characterized by pigment dilution with a striking pattern of dark areas termed primitive markings. Here we show that pigment dilution in Dun horses is due to radially asymmetric deposition of pigment in the growing hair caused by localized expression of the T-box 3 (TBX3) transcription factor in hair follicles, which in turn determines the distribution of hair follicle melanocytes. Most domestic horses are non-dun, a more intensely pigmented phenotype caused by regulatory mutations impairing TBX3 expression in the hair follicle, resulting in a more circumferential distribution of melanocytes and pigment granules in individual hairs. We identified two different alleles (non-dun1 and non-dun2) causing non-dun color. non-dun2 is a recently derived allele, whereas the Dun and non-dun1 alleles are found in ancient horse DNA, demonstrating that this polymorphism predates horse domestication. These findings uncover a new developmental role for T-box genes and new aspects of hair follicle biology and pigmentation.

AB - Dun is a wild-type coat color in horses characterized by pigment dilution with a striking pattern of dark areas termed primitive markings. Here we show that pigment dilution in Dun horses is due to radially asymmetric deposition of pigment in the growing hair caused by localized expression of the T-box 3 (TBX3) transcription factor in hair follicles, which in turn determines the distribution of hair follicle melanocytes. Most domestic horses are non-dun, a more intensely pigmented phenotype caused by regulatory mutations impairing TBX3 expression in the hair follicle, resulting in a more circumferential distribution of melanocytes and pigment granules in individual hairs. We identified two different alleles (non-dun1 and non-dun2) causing non-dun color. non-dun2 is a recently derived allele, whereas the Dun and non-dun1 alleles are found in ancient horse DNA, demonstrating that this polymorphism predates horse domestication. These findings uncover a new developmental role for T-box genes and new aspects of hair follicle biology and pigmentation.

U2 - 10.1038/ng.3475

DO - 10.1038/ng.3475

M3 - Journal article

VL - 48

SP - 152

EP - 158

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 2

ER -

ID: 160577096