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Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • J Davidsson
  • K Paulsson
  • D Lindgren
  • H Lilljebjörn
  • T Chaplin
  • E Forestier
  • M K Andersen
  • A Nordgren
  • R Rosenquist
  • T Fioretos
  • B D Young
  • B Johansson
Although childhood high hyperdiploid acute lymphoblastic leukemia is associated with a favorable outcome, 20% of patients still relapse. It is important to identify these patients already at diagnosis to ensure proper risk stratification. We have investigated 11 paired diagnostic and relapse samples with single nucleotide polymorphism array and mutation analyses of FLT3, KRAS, NRAS and PTPN11 in order to identify changes associated with relapse and to ascertain the genetic evolution patterns. Structural changes, mainly cryptic hemizygous deletions, were significantly more common at relapse (P
OriginalsprogEngelsk
TidsskriftLeukemia
Vol/bind24
Udgave nummer5
Sider (fra-til)924-31
Antal sider8
ISSN0887-6924
DOI
StatusUdgivet - 1 maj 2010

ID: 34112378