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Relative bioavailability of methadone hydrochloride administered in chewing gum and tablets

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Methadone administered in chewing gum in doses of 16.7-22.6 mg to seven patients in a study using an open balanced cross-over design, was compared with 20 mg of methadone given perorally as tablets. There was no significant difference in the AUC/D obtained after administration of chewing gum and tablets (p>0.05). It is concluded that the chewing gum formulation should be considered for further testing with respect to suppression of abstinence syndrome in narcotic addicts.
OriginalsprogEngelsk
TidsskriftActa Pharmaceutica Nordica
Vol/bind2
Udgave nummer2
Sider (fra-til)83-88
Antal sider6
ISSN1100-1801
StatusUdgivet - 1 jan. 1990

ID: 46100403