Forskning ved Københavns Universitet - Københavns Universitet

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Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Matthieu Allez
  • Konstantinos Karmiris
  • Edouard Louis
  • Gert Van Assche
  • Shomron Ben-Horin
  • Amir Klein
  • Janneke Van der Woude
  • Filip Baert
  • Rami Eliakim
  • Konstantinos Katsanos
  • Jørn Brynskov
  • Flavio Steinwurz
  • Silvio Danese
  • Severine Vermeire
  • Jean-Luc Teillaud
  • Marc Lémann
  • Yehuda Chowers
The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways.
OriginalsprogEngelsk
TidsskriftJournal of Crohn's and Colitis
Vol/bind4
Udgave nummer4
Sider (fra-til)355-66
Antal sider12
ISSN1873-9946
DOI
StatusUdgivet - 1 okt. 2010

ID: 34167290