Forskning ved Københavns Universitet - Københavns Universitet


Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Matthieu Allez
  • Konstantinos Karmiris
  • Edouard Louis
  • Gert Van Assche
  • Shomron Ben-Horin
  • Amir Klein
  • Janneke Van der Woude
  • Filip Baert
  • Rami Eliakim
  • Konstantinos Katsanos
  • Jørn Brynskov
  • Flavio Steinwurz
  • Silvio Danese
  • Severine Vermeire
  • Jean-Luc Teillaud
  • Marc Lémann
  • Yehuda Chowers
The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways.
TidsskriftJournal of Crohn's and Colitis
Udgave nummer4
Sider (fra-til)355-66
Antal sider12
StatusUdgivet - 1 okt. 2010

ID: 34167290