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Reproductive history and allergic rhinitis among 31145 Danish women

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Reproductive history and allergic rhinitis among 31145 Danish women. / Westergaard, Tine; Begtrup, K.; Rostgaard, K.; Krause, T. G.; Benn, C. S.; Melbye, M.

I: Clinical and Experimental Allergy, Bind 33, Nr. 3, 01.03.2003, s. 301-305.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Westergaard, T, Begtrup, K, Rostgaard, K, Krause, TG, Benn, CS & Melbye, M 2003, 'Reproductive history and allergic rhinitis among 31145 Danish women', Clinical and Experimental Allergy, bind 33, nr. 3, s. 301-305. https://doi.org/10.1046/j.1365-2222.2003.01441.x

APA

Westergaard, T., Begtrup, K., Rostgaard, K., Krause, T. G., Benn, C. S., & Melbye, M. (2003). Reproductive history and allergic rhinitis among 31145 Danish women. Clinical and Experimental Allergy, 33(3), 301-305. https://doi.org/10.1046/j.1365-2222.2003.01441.x

Vancouver

Westergaard T, Begtrup K, Rostgaard K, Krause TG, Benn CS, Melbye M. Reproductive history and allergic rhinitis among 31145 Danish women. Clinical and Experimental Allergy. 2003 mar 1;33(3):301-305. https://doi.org/10.1046/j.1365-2222.2003.01441.x

Author

Westergaard, Tine ; Begtrup, K. ; Rostgaard, K. ; Krause, T. G. ; Benn, C. S. ; Melbye, M. / Reproductive history and allergic rhinitis among 31145 Danish women. I: Clinical and Experimental Allergy. 2003 ; Bind 33, Nr. 3. s. 301-305.

Bibtex

@article{40a3c08fb7ff40a18bd4c5ddebd18b8b,
title = "Reproductive history and allergic rhinitis among 31145 Danish women",
abstract = "Background and objective: A successful pregnancy is associated with a strong skewing of the immune system towards a Th2-type immune response. Because such a deviation is also the hallmark of allergic disease, it was investigated whether allergic rhinitis in women was associated with an increased likelihood of becoming pregnant and having a successful outcome of pregnancies. Material and methods: Information on allergic rhinitis and reproductive history was obtained for 31145 pregnant women who participated in a national birth cohort study in Denmark during September 1997 to March 2000, and for whom complete information on siblings and place of residence and birth was available via the Civil Registration System. Data were analysed using logistic regression. Results: Women who had previously been pregnant (OR = 0.91,95% CI 0.85-0.98) or who had given birth previously (OR = 0.91, 95% CI 0.85-0.98) were less likely to report allergic rhinitis than others. The number of previous spontaneous abortions, gestational week of the first spontaneous abortion and fertility treatment were not associated with allergic rhinitis. Women who had waited less than a year to become pregnant more often had allergic rhinitis (OR = 1.18, 95% CI 1.06-1.32, P= 0.002) than women who had waited for more than a year. Early age at menarche was associated with an increased likelihood of allergic rhinitis (Ptrend=0.003). Conclusions: Our findings did not support the hypothesis that an atopic genotype overall should be associated with an increased likelihood of successful outcome of pregnancies, but it might be associated with a decreased waiting time to pregnancy.",
keywords = "Allergic rhinitis, Allergy, Epidemiology, Fertility, Menarche, Parity, Pregnancy, Reproductive history, Spontaneous abortion, Th2",
author = "Tine Westergaard and K. Begtrup and K. Rostgaard and Krause, {T. G.} and Benn, {C. S.} and M. Melbye",
year = "2003",
month = mar,
day = "1",
doi = "10.1046/j.1365-2222.2003.01441.x",
language = "English",
volume = "33",
pages = "301--305",
journal = "Clinical and Experimental Allergy",
issn = "0954-7894",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Reproductive history and allergic rhinitis among 31145 Danish women

AU - Westergaard, Tine

AU - Begtrup, K.

AU - Rostgaard, K.

AU - Krause, T. G.

AU - Benn, C. S.

AU - Melbye, M.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Background and objective: A successful pregnancy is associated with a strong skewing of the immune system towards a Th2-type immune response. Because such a deviation is also the hallmark of allergic disease, it was investigated whether allergic rhinitis in women was associated with an increased likelihood of becoming pregnant and having a successful outcome of pregnancies. Material and methods: Information on allergic rhinitis and reproductive history was obtained for 31145 pregnant women who participated in a national birth cohort study in Denmark during September 1997 to March 2000, and for whom complete information on siblings and place of residence and birth was available via the Civil Registration System. Data were analysed using logistic regression. Results: Women who had previously been pregnant (OR = 0.91,95% CI 0.85-0.98) or who had given birth previously (OR = 0.91, 95% CI 0.85-0.98) were less likely to report allergic rhinitis than others. The number of previous spontaneous abortions, gestational week of the first spontaneous abortion and fertility treatment were not associated with allergic rhinitis. Women who had waited less than a year to become pregnant more often had allergic rhinitis (OR = 1.18, 95% CI 1.06-1.32, P= 0.002) than women who had waited for more than a year. Early age at menarche was associated with an increased likelihood of allergic rhinitis (Ptrend=0.003). Conclusions: Our findings did not support the hypothesis that an atopic genotype overall should be associated with an increased likelihood of successful outcome of pregnancies, but it might be associated with a decreased waiting time to pregnancy.

AB - Background and objective: A successful pregnancy is associated with a strong skewing of the immune system towards a Th2-type immune response. Because such a deviation is also the hallmark of allergic disease, it was investigated whether allergic rhinitis in women was associated with an increased likelihood of becoming pregnant and having a successful outcome of pregnancies. Material and methods: Information on allergic rhinitis and reproductive history was obtained for 31145 pregnant women who participated in a national birth cohort study in Denmark during September 1997 to March 2000, and for whom complete information on siblings and place of residence and birth was available via the Civil Registration System. Data were analysed using logistic regression. Results: Women who had previously been pregnant (OR = 0.91,95% CI 0.85-0.98) or who had given birth previously (OR = 0.91, 95% CI 0.85-0.98) were less likely to report allergic rhinitis than others. The number of previous spontaneous abortions, gestational week of the first spontaneous abortion and fertility treatment were not associated with allergic rhinitis. Women who had waited less than a year to become pregnant more often had allergic rhinitis (OR = 1.18, 95% CI 1.06-1.32, P= 0.002) than women who had waited for more than a year. Early age at menarche was associated with an increased likelihood of allergic rhinitis (Ptrend=0.003). Conclusions: Our findings did not support the hypothesis that an atopic genotype overall should be associated with an increased likelihood of successful outcome of pregnancies, but it might be associated with a decreased waiting time to pregnancy.

KW - Allergic rhinitis

KW - Allergy

KW - Epidemiology

KW - Fertility

KW - Menarche

KW - Parity

KW - Pregnancy

KW - Reproductive history

KW - Spontaneous abortion

KW - Th2

UR - http://www.scopus.com/inward/record.url?scp=0037335762&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2222.2003.01441.x

DO - 10.1046/j.1365-2222.2003.01441.x

M3 - Journal article

C2 - 12614442

AN - SCOPUS:0037335762

VL - 33

SP - 301

EP - 305

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

SN - 0954-7894

IS - 3

ER -

ID: 259460915