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Rituximab (MabThera) til behandling af aktiv reumatoid artritis

Publikation: Bidrag til tidsskriftTidsskriftartikel

Rituximab (RTX) is a murine/human monoclonal antibody to CD20, a protein expressed almost exclusively on human B-lymphocytes. RTX induces rapid and marked B-cell depletion with beneficial clinical effects in 1/3 to 1/2 of rheumatoid arthritis patients. Treatment is given as two iv. infusions with a two-week interval and in combination with methotrexate. Mild to moderate side-effects are frequent, particularly during the first infusion, but long-term side-effects are generally rare, although pulmonary events and reactivation of viral infections of the liver is of concern.
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind168
Udgave nummer47
Sider (fra-til)4079-81
Antal sider3
ISSN0041-5782
StatusUdgivet - 20 nov. 2006

ID: 34072599