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Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

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Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. / Angelillo-Scherrer, Anne; Burnier, Laurent Pierre; Flores, Nathalie; Savi, Pierre; DeMol, Maria; Schaeffer, Paul; Herbert, Jean-Marc; Lemke, Greg; Goff, Stephen P; Matsushima, Glenn K; Earp, H Shelton; Vesin, Christian; Hoylaerts, Marc F; Plaisance, Stéphane; Collen, Désiré; Conway, Edward M; Wehrle-Haller, Bernhard; Carmeliet, Peter.

I: The Journal of Clinical Investigation, Bind 115, Nr. 2, 02.2005, s. 237-46.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Angelillo-Scherrer, A, Burnier, LP, Flores, N, Savi, P, DeMol, M, Schaeffer, P, Herbert, J-M, Lemke, G, Goff, SP, Matsushima, GK, Earp, HS, Vesin, C, Hoylaerts, MF, Plaisance, S, Collen, D, Conway, EM, Wehrle-Haller, B & Carmeliet, P 2005, 'Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy', The Journal of Clinical Investigation, bind 115, nr. 2, s. 237-46. https://doi.org/10.1172/JCI22079

APA

Angelillo-Scherrer, A., Burnier, L. P., Flores, N., Savi, P., DeMol, M., Schaeffer, P., ... Carmeliet, P. (2005). Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. The Journal of Clinical Investigation, 115(2), 237-46. https://doi.org/10.1172/JCI22079

Vancouver

Angelillo-Scherrer A, Burnier LP, Flores N, Savi P, DeMol M, Schaeffer P o.a. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. The Journal of Clinical Investigation. 2005 feb;115(2):237-46. https://doi.org/10.1172/JCI22079

Author

Angelillo-Scherrer, Anne ; Burnier, Laurent Pierre ; Flores, Nathalie ; Savi, Pierre ; DeMol, Maria ; Schaeffer, Paul ; Herbert, Jean-Marc ; Lemke, Greg ; Goff, Stephen P ; Matsushima, Glenn K ; Earp, H Shelton ; Vesin, Christian ; Hoylaerts, Marc F ; Plaisance, Stéphane ; Collen, Désiré ; Conway, Edward M ; Wehrle-Haller, Bernhard ; Carmeliet, Peter. / Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. I: The Journal of Clinical Investigation. 2005 ; Bind 115, Nr. 2. s. 237-46.

Bibtex

@article{e7f7acc9f6d4441c8eb4835c1227bfce,
title = "Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy",
abstract = "Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a soluble extracellular domain of Axl that traps Gas6 protects mice against life-threatening thrombosis. Loss of a Gas6-R does not prevent initial platelet aggregation but impairs subsequent stabilization of platelet aggregates, at least in part by reducing {"}outside-in{"} signaling and platelet granule secretion. Gas6, through its receptors, activates PI3K and Akt and stimulates tyrosine phosphorylation of the beta3 integrin, thereby amplifying outside-in signaling via alphaIIbbeta3. Blocking the Gas6-R-alphaIIbbeta3 integrin cross-talk might be a novel approach to the reduction of thrombosis.",
keywords = "Animals, Integrin beta3, Intercellular Signaling Peptides and Proteins, Mice, Mice, Knockout, Phosphatidylinositol 3-Kinases, Platelet Aggregation, Platelet Glycoprotein GPIIb-IIIa Complex, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Receptor Protein-Tyrosine Kinases, Signal Transduction, Thrombosis",
author = "Anne Angelillo-Scherrer and Burnier, {Laurent Pierre} and Nathalie Flores and Pierre Savi and Maria DeMol and Paul Schaeffer and Jean-Marc Herbert and Greg Lemke and Goff, {Stephen P} and Matsushima, {Glenn K} and Earp, {H Shelton} and Christian Vesin and Hoylaerts, {Marc F} and St{\'e}phane Plaisance and D{\'e}sir{\'e} Collen and Conway, {Edward M} and Bernhard Wehrle-Haller and Peter Carmeliet",
year = "2005",
month = "2",
doi = "10.1172/JCI22079",
language = "English",
volume = "115",
pages = "237--46",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "American Society for Clinical Investigation",
number = "2",

}

RIS

TY - JOUR

T1 - Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

AU - Angelillo-Scherrer, Anne

AU - Burnier, Laurent Pierre

AU - Flores, Nathalie

AU - Savi, Pierre

AU - DeMol, Maria

AU - Schaeffer, Paul

AU - Herbert, Jean-Marc

AU - Lemke, Greg

AU - Goff, Stephen P

AU - Matsushima, Glenn K

AU - Earp, H Shelton

AU - Vesin, Christian

AU - Hoylaerts, Marc F

AU - Plaisance, Stéphane

AU - Collen, Désiré

AU - Conway, Edward M

AU - Wehrle-Haller, Bernhard

AU - Carmeliet, Peter

PY - 2005/2

Y1 - 2005/2

N2 - Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a soluble extracellular domain of Axl that traps Gas6 protects mice against life-threatening thrombosis. Loss of a Gas6-R does not prevent initial platelet aggregation but impairs subsequent stabilization of platelet aggregates, at least in part by reducing "outside-in" signaling and platelet granule secretion. Gas6, through its receptors, activates PI3K and Akt and stimulates tyrosine phosphorylation of the beta3 integrin, thereby amplifying outside-in signaling via alphaIIbbeta3. Blocking the Gas6-R-alphaIIbbeta3 integrin cross-talk might be a novel approach to the reduction of thrombosis.

AB - Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a soluble extracellular domain of Axl that traps Gas6 protects mice against life-threatening thrombosis. Loss of a Gas6-R does not prevent initial platelet aggregation but impairs subsequent stabilization of platelet aggregates, at least in part by reducing "outside-in" signaling and platelet granule secretion. Gas6, through its receptors, activates PI3K and Akt and stimulates tyrosine phosphorylation of the beta3 integrin, thereby amplifying outside-in signaling via alphaIIbbeta3. Blocking the Gas6-R-alphaIIbbeta3 integrin cross-talk might be a novel approach to the reduction of thrombosis.

KW - Animals

KW - Integrin beta3

KW - Intercellular Signaling Peptides and Proteins

KW - Mice

KW - Mice, Knockout

KW - Phosphatidylinositol 3-Kinases

KW - Platelet Aggregation

KW - Platelet Glycoprotein GPIIb-IIIa Complex

KW - Protein-Serine-Threonine Kinases

KW - Proto-Oncogene Proteins

KW - Proto-Oncogene Proteins c-akt

KW - Receptor Protein-Tyrosine Kinases

KW - Signal Transduction

KW - Thrombosis

U2 - 10.1172/JCI22079

DO - 10.1172/JCI22079

M3 - Journal article

C2 - 15650770

VL - 115

SP - 237

EP - 246

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 2

ER -

ID: 100892334