Forskning ved Københavns Universitet - Københavns Universitet

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Role of hepatic resection for patients with carcinoid heart disease

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • A.M. Bernheim
  • H.M. Connolly
  • J. Rubin
  • Jacob Eifer Møller
  • C.G. Scott
  • D.M. Nagorney
  • P.A. Pellikka
OBJECTIVE: To evaluate the effects of resection of hepatic carcinoid metastases on progression and prognosis of carcinoid heart disease. PATIENTS AND METHODS: From our database of 265 consecutive patients diagnosed as having carcinoid heart disease from January 1, 1980, through December 31, 2005, we calculated survival from first diagnosis of cardiac involvement. Hepatic resection during follow-up was entered as a time-dependent covariable in a multivariable analysis. In patients with serial echocardiograms more than 1 year apart without intervening cardiac surgery, a previously validated cardiac severity score was calculated. A score increase that exceeded 25% was considered relevant progression. RESULTS: Hepatic resection was performed in 31 patients (12%) during follow-up. Five-year survival was significantly higher in these patients (86.5%; 95% confidence interval [CI], 73.5%-100.0%) than in patients without hepatic resection (29.0%; 95% CI, 23.3%-36.1%; univariable hazard ratio for hepatic resection, 0.25; 95% CI 0.12-0.53; P<.001). Hepatic resection remained strongly associated with improved prognosis in multivariable analysis (hazard ratio, 0.31; 95% CI, 0.14-0.66; P=.003). Among 77 patients (29%) with serial echocardiograms, 10 (13%) underwent hepatic resection during follow-up; resection was independently associated with decreased risk of cardiac progression (odds ratio, 0.29; 95% CI, 0.06-0.75; P=.03). CONCLUSION: Despite the limitations of this retrospective nonrandomized study, our data suggest that patients with carcinoid heart disease who undergo hepatic resection have decreased cardiac progression and improved prognosis. Eligible patients should be considered for hepatic surgery
Udgivelsesdato: 2008/2
OriginalsprogEngelsk
TidsskriftMayo Clinic Proceedings
Vol/bind83
Udgave nummer2
Sider (fra-til)143-150
Antal sider7
ISSN0025-6196
StatusUdgivet - 2008

ID: 10920772