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RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

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Standard

RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome. / Wu, Wei; Bhowmick, Rahul; Vogel, Ivan; Özer, Özgün; Ghisays, Fiorella; Thakur, Roshan S; Sanchez de Leon, Esther; Richter, Philipp H; Ren, Liqun; Petrini, John H; Hickson, Ian D; Liu, Ying.

I: Nature Structural & Molecular Biology, Bind 27, Nr. 5, 05.2020, s. 424-437.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Wu, W, Bhowmick, R, Vogel, I, Özer, Ö, Ghisays, F, Thakur, RS, Sanchez de Leon, E, Richter, PH, Ren, L, Petrini, JH, Hickson, ID & Liu, Y 2020, 'RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome', Nature Structural & Molecular Biology, bind 27, nr. 5, s. 424-437. https://doi.org/10.1038/s41594-020-0408-6

APA

Wu, W., Bhowmick, R., Vogel, I., Özer, Ö., Ghisays, F., Thakur, R. S., ... Liu, Y. (2020). RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome. Nature Structural & Molecular Biology, 27(5), 424-437. https://doi.org/10.1038/s41594-020-0408-6

Vancouver

Wu W, Bhowmick R, Vogel I, Özer Ö, Ghisays F, Thakur RS o.a. RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome. Nature Structural & Molecular Biology. 2020 maj;27(5):424-437. https://doi.org/10.1038/s41594-020-0408-6

Author

Wu, Wei ; Bhowmick, Rahul ; Vogel, Ivan ; Özer, Özgün ; Ghisays, Fiorella ; Thakur, Roshan S ; Sanchez de Leon, Esther ; Richter, Philipp H ; Ren, Liqun ; Petrini, John H ; Hickson, Ian D ; Liu, Ying. / RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome. I: Nature Structural & Molecular Biology. 2020 ; Bind 27, Nr. 5. s. 424-437.

Bibtex

@article{786984a542324006b4bb402684d2e103,
title = "RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome",
abstract = "Oncogene activation during tumorigenesis generates DNA replication stress, a known driver of genome rearrangements. In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and subsequently complete locus duplication in mitosis in a process known as 'MiDAS'. Here, we demonstrate that RTEL1 (regulator of telomere elongation helicase 1) has a genome-wide role in MiDAS at loci prone to form G-quadruplex-associated R-loops, in a process that is dependent on its helicase function. We reveal that SLX4 is required for the timely recruitment of RTEL1 to the affected loci, which in turn facilitates recruitment of other proteins required for MiDAS, including RAD52 and POLD3. Our findings demonstrate that RTEL1 is required for MiDAS and suggest that RTEL1 maintains genome stability by resolving conflicts that can arise between the replication and transcription machineries.",
author = "Wei Wu and Rahul Bhowmick and Ivan Vogel and {\"O}zg{\"u}n {\"O}zer and Fiorella Ghisays and Thakur, {Roshan S} and {Sanchez de Leon}, Esther and Richter, {Philipp H} and Liqun Ren and Petrini, {John H} and Hickson, {Ian D} and Ying Liu",
year = "2020",
month = "5",
doi = "10.1038/s41594-020-0408-6",
language = "English",
volume = "27",
pages = "424--437",
journal = "Nature Structural and Molecular Biology",
issn = "1545-9993",
publisher = "nature publishing group",
number = "5",

}

RIS

TY - JOUR

T1 - RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome

AU - Wu, Wei

AU - Bhowmick, Rahul

AU - Vogel, Ivan

AU - Özer, Özgün

AU - Ghisays, Fiorella

AU - Thakur, Roshan S

AU - Sanchez de Leon, Esther

AU - Richter, Philipp H

AU - Ren, Liqun

AU - Petrini, John H

AU - Hickson, Ian D

AU - Liu, Ying

PY - 2020/5

Y1 - 2020/5

N2 - Oncogene activation during tumorigenesis generates DNA replication stress, a known driver of genome rearrangements. In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and subsequently complete locus duplication in mitosis in a process known as 'MiDAS'. Here, we demonstrate that RTEL1 (regulator of telomere elongation helicase 1) has a genome-wide role in MiDAS at loci prone to form G-quadruplex-associated R-loops, in a process that is dependent on its helicase function. We reveal that SLX4 is required for the timely recruitment of RTEL1 to the affected loci, which in turn facilitates recruitment of other proteins required for MiDAS, including RAD52 and POLD3. Our findings demonstrate that RTEL1 is required for MiDAS and suggest that RTEL1 maintains genome stability by resolving conflicts that can arise between the replication and transcription machineries.

AB - Oncogene activation during tumorigenesis generates DNA replication stress, a known driver of genome rearrangements. In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and subsequently complete locus duplication in mitosis in a process known as 'MiDAS'. Here, we demonstrate that RTEL1 (regulator of telomere elongation helicase 1) has a genome-wide role in MiDAS at loci prone to form G-quadruplex-associated R-loops, in a process that is dependent on its helicase function. We reveal that SLX4 is required for the timely recruitment of RTEL1 to the affected loci, which in turn facilitates recruitment of other proteins required for MiDAS, including RAD52 and POLD3. Our findings demonstrate that RTEL1 is required for MiDAS and suggest that RTEL1 maintains genome stability by resolving conflicts that can arise between the replication and transcription machineries.

U2 - 10.1038/s41594-020-0408-6

DO - 10.1038/s41594-020-0408-6

M3 - Journal article

C2 - 32398827

VL - 27

SP - 424

EP - 437

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

SN - 1545-9993

IS - 5

ER -

ID: 241416967