Forskning ved Københavns Universitet - Københavns Universitet


Safety of Intranasal Fentanyl in the Out-of-Hospital Setting: A Prospective Observational Study

Publikation: Bidrag til tidsskriftTidsskriftartikel

  • Anders P H Karlsen
  • Danny M B Pedersen
  • Sven Trautner
  • Jørgen B Dahl
  • Morten S Hansen

STUDY OBJECTIVE: Initial out-of-hospital analgesia is sometimes hampered by difficulties in achieving intravenous access or lack of skills in administering intravenous opioids. We study the safety profile and apparent analgesic effect of intranasal fentanyl in the out-of-hospital setting.

METHODS: In this prospective observational study, we administered intranasal fentanyl in the out-of-hospital setting to adults and children older than 8 years with severe pain resulting from orthopedic conditions, abdominal pain, or acute coronary syndrome refractory to nitroglycerin spray. Patients received 1 to 3 doses of either 50 or 100 μg, and the ambulance crew recorded adverse effects and numeric rating scale (0 to 10) pain scores before and after treatment.

RESULTS: Our 903 evaluable patients received a mean cumulative fentanyl dose of 114 μg (range 50 to 300 μg). There were no serious adverse effects and no use of naloxone. Thirty-six patients (4%) experienced mild adverse effects: mild hypotension, nausea, vomiting, vertigo, abdominal pain, rash, or decrease of Glasgow Coma Scale score to 14. The median reduction in pain score was 3 (interquartile range 2 to 5) after fentanyl administration.

CONCLUSION: The out-of-hospital administration of intranasal fentanyl in doses of 50 to 100 μg is safe and appears effective.

TidsskriftAcademic Emergency Medicine
Udgave nummer6
Sider (fra-til)699-703
Antal sider5
StatusUdgivet - jun. 2014

ID: 138778033