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Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp

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A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 µg/mL, 8.3 µM).
OriginalsprogEngelsk
TidsskriftOrganic Letters
Vol/bind13
Udgave nummer4
Sider (fra-til)752-755
Antal sider4
ISSN1523-7060
DOI
StatusUdgivet - 2011

ID: 33075263