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Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population—A Nationwide Register Study

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Standard

Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population—A Nationwide Register Study. / Vangkilde, Anders; Olsen, Line; Hoeffding, Louise K E; Pedersen, Carsten B; Mortensen, Preben B; Werge, Thomas; Trabjerg, Betina.

I: Schizophrenia Bulletin, Bind 42, Nr. 3, 05.2016, s. 824-31.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Vangkilde, A, Olsen, L, Hoeffding, LKE, Pedersen, CB, Mortensen, PB, Werge, T & Trabjerg, B 2016, 'Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population—A Nationwide Register Study', Schizophrenia Bulletin, bind 42, nr. 3, s. 824-31. https://doi.org/10.1093/schbul/sbv195

APA

Vangkilde, A., Olsen, L., Hoeffding, L. K. E., Pedersen, C. B., Mortensen, P. B., Werge, T., & Trabjerg, B. (2016). Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population—A Nationwide Register Study. Schizophrenia Bulletin, 42(3), 824-31. https://doi.org/10.1093/schbul/sbv195

Vancouver

Vangkilde A, Olsen L, Hoeffding LKE, Pedersen CB, Mortensen PB, Werge T o.a. Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population—A Nationwide Register Study. Schizophrenia Bulletin. 2016 maj;42(3):824-31. https://doi.org/10.1093/schbul/sbv195

Author

Vangkilde, Anders ; Olsen, Line ; Hoeffding, Louise K E ; Pedersen, Carsten B ; Mortensen, Preben B ; Werge, Thomas ; Trabjerg, Betina. / Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population—A Nationwide Register Study. I: Schizophrenia Bulletin. 2016 ; Bind 42, Nr. 3. s. 824-31.

Bibtex

@article{5851b6da1ffb4aa78fdcadc6a5915aaa,
title = "Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population—A Nationwide Register Study",
abstract = "OBJECTIVE: Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22q11.2 deletion syndrome.METHODS: Danish nationwide registers were linked to establish a cohort consisting of all Danish citizens born during 1955-2004 and the cohort was followed from January 1, 1994 until December 31, 2013. Data were analyzed using survival analyses and adjusted for calendar year, age, sex, and parental mental health history.RESULTS: A total of 156 individuals with 22q11.2 deletion syndrome were identified, out of which 6 individuals were diagnosed with schizophrenia spectrum disorders following identification with 22q11 deletion syndrome. Identified carriers of 22q11.2 deletion had an 8.13(95% CI: 3.65-18.09) fold increased risk of schizophrenia spectrum disorder.CONCLUSIONS: Carriers of a 22q11.2 deletion who had been clinically identified had a highly increased risk of schizophrenia spectrum disorders.",
keywords = "Adolescent, Adult, Child, Cohort Studies, Comorbidity, Denmark, DiGeorge Syndrome, Female, Humans, Male, Middle Aged, Registries, Schizophrenia, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",
author = "Anders Vangkilde and Line Olsen and Hoeffding, {Louise K E} and Pedersen, {Carsten B} and Mortensen, {Preben B} and Thomas Werge and Betina Trabjerg",
note = "{\textcopyright} The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2016",
month = may,
doi = "10.1093/schbul/sbv195",
language = "English",
volume = "42",
pages = "824--31",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population—A Nationwide Register Study

AU - Vangkilde, Anders

AU - Olsen, Line

AU - Hoeffding, Louise K E

AU - Pedersen, Carsten B

AU - Mortensen, Preben B

AU - Werge, Thomas

AU - Trabjerg, Betina

N1 - © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2016/5

Y1 - 2016/5

N2 - OBJECTIVE: Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22q11.2 deletion syndrome.METHODS: Danish nationwide registers were linked to establish a cohort consisting of all Danish citizens born during 1955-2004 and the cohort was followed from January 1, 1994 until December 31, 2013. Data were analyzed using survival analyses and adjusted for calendar year, age, sex, and parental mental health history.RESULTS: A total of 156 individuals with 22q11.2 deletion syndrome were identified, out of which 6 individuals were diagnosed with schizophrenia spectrum disorders following identification with 22q11 deletion syndrome. Identified carriers of 22q11.2 deletion had an 8.13(95% CI: 3.65-18.09) fold increased risk of schizophrenia spectrum disorder.CONCLUSIONS: Carriers of a 22q11.2 deletion who had been clinically identified had a highly increased risk of schizophrenia spectrum disorders.

AB - OBJECTIVE: Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22q11.2 deletion syndrome.METHODS: Danish nationwide registers were linked to establish a cohort consisting of all Danish citizens born during 1955-2004 and the cohort was followed from January 1, 1994 until December 31, 2013. Data were analyzed using survival analyses and adjusted for calendar year, age, sex, and parental mental health history.RESULTS: A total of 156 individuals with 22q11.2 deletion syndrome were identified, out of which 6 individuals were diagnosed with schizophrenia spectrum disorders following identification with 22q11 deletion syndrome. Identified carriers of 22q11.2 deletion had an 8.13(95% CI: 3.65-18.09) fold increased risk of schizophrenia spectrum disorder.CONCLUSIONS: Carriers of a 22q11.2 deletion who had been clinically identified had a highly increased risk of schizophrenia spectrum disorders.

KW - Adolescent

KW - Adult

KW - Child

KW - Cohort Studies

KW - Comorbidity

KW - Denmark

KW - DiGeorge Syndrome

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Registries

KW - Schizophrenia

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1093/schbul/sbv195

DO - 10.1093/schbul/sbv195

M3 - Journal article

C2 - 26738530

VL - 42

SP - 824

EP - 831

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 3

ER -

ID: 177524934