Forskning ved Københavns Universitet - Københavns Universitet

Forside

SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

The importance of the sesquiterpene lactone thapsigargin as a tool for studying Ca2+ homeostasis has created a need for structure-activity relationship studies and consequently for procedures for selective transformations of the functional groups in the molecule. Methods for the selective inversion of configuration at C-3 and C-8, selective acetylation, and selective cleavage of the ester groups at 0-3, 0-8 and 0-10 are presented.
OriginalsprogUdefineret/Ukendt
TidsskriftActa Chemica Scandinavica. Supplementum
Vol/bind48
Udgave nummer4
Sider (fra-til)340-346
Antal sider7
ISSN0065-1133
StatusUdgivet - 1994

    Forskningsområder

  • ca2+ transport atpases reticulum ca-2+-atpase thapsia-garganica tumor promoter high-affinity

ID: 38061031