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Serum aminoterminal type III procollagen peptide in early rheumatoid arthritis: relation to disease activity and progression of joint damage

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Standard

Serum aminoterminal type III procollagen peptide in early rheumatoid arthritis : relation to disease activity and progression of joint damage. / Eberhardt, K; Jensen, Lars Thorbjørn; Horslev-Petersen, K; Pettersson, H; Lorenzen, I; Wollheim, F.

I: Clinical and Experimental Rheumatology, Bind 8, Nr. 4, 01.07.1990, s. 335-40.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Eberhardt, K, Jensen, LT, Horslev-Petersen, K, Pettersson, H, Lorenzen, I & Wollheim, F 1990, 'Serum aminoterminal type III procollagen peptide in early rheumatoid arthritis: relation to disease activity and progression of joint damage', Clinical and Experimental Rheumatology, bind 8, nr. 4, s. 335-40.

APA

Eberhardt, K., Jensen, L. T., Horslev-Petersen, K., Pettersson, H., Lorenzen, I., & Wollheim, F. (1990). Serum aminoterminal type III procollagen peptide in early rheumatoid arthritis: relation to disease activity and progression of joint damage. Clinical and Experimental Rheumatology, 8(4), 335-40.

Vancouver

Eberhardt K, Jensen LT, Horslev-Petersen K, Pettersson H, Lorenzen I, Wollheim F. Serum aminoterminal type III procollagen peptide in early rheumatoid arthritis: relation to disease activity and progression of joint damage. Clinical and Experimental Rheumatology. 1990 jul 1;8(4):335-40.

Author

Eberhardt, K ; Jensen, Lars Thorbjørn ; Horslev-Petersen, K ; Pettersson, H ; Lorenzen, I ; Wollheim, F. / Serum aminoterminal type III procollagen peptide in early rheumatoid arthritis : relation to disease activity and progression of joint damage. I: Clinical and Experimental Rheumatology. 1990 ; Bind 8, Nr. 4. s. 335-40.

Bibtex

@article{a6ee8ad071e4440ba447655e0ba5564a,
title = "Serum aminoterminal type III procollagen peptide in early rheumatoid arthritis: relation to disease activity and progression of joint damage",
abstract = "Serum levels of the aminoterminal type III procollagen peptide (S-PIIINP) have been used as markers of proliferative inflammation in rheumatoid arthritis (RA) and a prognostic significance has been suggested. To test this further we have measured S-PIIINP longitudinally for 2 years in 66 patients with definite RA and a disease duration of less than 2 years, and related the levels to clinical, biochemical, and radiographic findings. In this patient group the correlations between S-PIIINP and ESR and CRP, respectively, were higher than those obtained between S-PIIINP and articular indices, and markedly higher than in patients with RA of longer duration. Patients with normal mean levels of S-PIIINP during the study period had a significantly slower rate of radiographic progression than patients with elevated mean levels of S-PIIINP. ESR yielded in general higher correlations with the joint damage process than did S-PIIINP. The correlations between S-PIIINP and the joint damage scores increased with time. A multiple regression analysis showed that ESR explained most of the variance in joint damage progression over 2 years, but S-PIIINP added independent information. About one third of the variance could be explained by the two variables.",
keywords = "Arthritis, Rheumatoid, Arthrography, Blood Sedimentation, Female, Humans, Male, Middle Aged, Peptide Fragments, Procollagen, Regression Analysis, Sensitivity and Specificity, Journal Article, Research Support, Non-U.S. Gov't",
author = "K Eberhardt and Jensen, {Lars Thorbj{\o}rn} and K Horslev-Petersen and H Pettersson and I Lorenzen and F Wollheim",
year = "1990",
month = "7",
day = "1",
language = "English",
volume = "8",
pages = "335--40",
journal = "Clinical and Experimental Rheumatology",
issn = "0392-856X",
publisher = "Pacini Editore SpA",
number = "4",

}

RIS

TY - JOUR

T1 - Serum aminoterminal type III procollagen peptide in early rheumatoid arthritis

T2 - relation to disease activity and progression of joint damage

AU - Eberhardt, K

AU - Jensen, Lars Thorbjørn

AU - Horslev-Petersen, K

AU - Pettersson, H

AU - Lorenzen, I

AU - Wollheim, F

PY - 1990/7/1

Y1 - 1990/7/1

N2 - Serum levels of the aminoterminal type III procollagen peptide (S-PIIINP) have been used as markers of proliferative inflammation in rheumatoid arthritis (RA) and a prognostic significance has been suggested. To test this further we have measured S-PIIINP longitudinally for 2 years in 66 patients with definite RA and a disease duration of less than 2 years, and related the levels to clinical, biochemical, and radiographic findings. In this patient group the correlations between S-PIIINP and ESR and CRP, respectively, were higher than those obtained between S-PIIINP and articular indices, and markedly higher than in patients with RA of longer duration. Patients with normal mean levels of S-PIIINP during the study period had a significantly slower rate of radiographic progression than patients with elevated mean levels of S-PIIINP. ESR yielded in general higher correlations with the joint damage process than did S-PIIINP. The correlations between S-PIIINP and the joint damage scores increased with time. A multiple regression analysis showed that ESR explained most of the variance in joint damage progression over 2 years, but S-PIIINP added independent information. About one third of the variance could be explained by the two variables.

AB - Serum levels of the aminoterminal type III procollagen peptide (S-PIIINP) have been used as markers of proliferative inflammation in rheumatoid arthritis (RA) and a prognostic significance has been suggested. To test this further we have measured S-PIIINP longitudinally for 2 years in 66 patients with definite RA and a disease duration of less than 2 years, and related the levels to clinical, biochemical, and radiographic findings. In this patient group the correlations between S-PIIINP and ESR and CRP, respectively, were higher than those obtained between S-PIIINP and articular indices, and markedly higher than in patients with RA of longer duration. Patients with normal mean levels of S-PIIINP during the study period had a significantly slower rate of radiographic progression than patients with elevated mean levels of S-PIIINP. ESR yielded in general higher correlations with the joint damage process than did S-PIIINP. The correlations between S-PIIINP and the joint damage scores increased with time. A multiple regression analysis showed that ESR explained most of the variance in joint damage progression over 2 years, but S-PIIINP added independent information. About one third of the variance could be explained by the two variables.

KW - Arthritis, Rheumatoid

KW - Arthrography

KW - Blood Sedimentation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Peptide Fragments

KW - Procollagen

KW - Regression Analysis

KW - Sensitivity and Specificity

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 2204510

VL - 8

SP - 335

EP - 340

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 4

ER -

ID: 168819106