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Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction

Publikation: Bidrag til tidsskriftTidsskriftartikel

Standard

Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction. / Jensen, L T; Hørslev-Petersen, K; Toft, P; Bentsen, K D; Grande, P; Simonsen, E E; Lorenzen, I.

I: Circulation. Supplement, Bind 81, Nr. 1, 01.1990, s. 52-7.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Harvard

Jensen, LT, Hørslev-Petersen, K, Toft, P, Bentsen, KD, Grande, P, Simonsen, EE & Lorenzen, I 1990, 'Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction', Circulation. Supplement, bind 81, nr. 1, s. 52-7.

APA

Jensen, L. T., Hørslev-Petersen, K., Toft, P., Bentsen, K. D., Grande, P., Simonsen, E. E., & Lorenzen, I. (1990). Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction. Circulation. Supplement, 81(1), 52-7.

Vancouver

Jensen LT, Hørslev-Petersen K, Toft P, Bentsen KD, Grande P, Simonsen EE o.a. Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction. Circulation. Supplement. 1990 jan;81(1):52-7.

Author

Jensen, L T ; Hørslev-Petersen, K ; Toft, P ; Bentsen, K D ; Grande, P ; Simonsen, E E ; Lorenzen, I. / Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction. I: Circulation. Supplement. 1990 ; Bind 81, Nr. 1. s. 52-7.

Bibtex

@article{e11a47ac45884f308a92b6382251d0dd,
title = "Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction",
abstract = "In 16 patients with acute myocardial infarction and in 15 controls, procollagen type III aminoterminal peptide in serum (PIIINP) was measured consecutively. Serum PIIINP was increased on the second to third postinfarction day (p less than 0.01) and remained elevated for more than 4 months. Peak values were observed on the third to seventh postinfarction day. The individual peak changes were correlated to infarction size calculated from serum CK-MB and serum lactate dehydrogenase (p = 0.60, p = 0.02). The changes in distribution of PIIINP-related antigens in serum after gel chromatography were similar to changes observed during wound healing in humans. PIIINP is cleaved off procollagen type III during the biosynthesis of type III collagen, which characterizes the early stages of repair and inflammation. Our findings suggest that serum PIIINP reflects the repair processes and scar formation following acute myocardial infarction. The serum PIIINP alterations in acute myocardial infarction differ essentially from the changes in myocardial enzymes reflecting myocardial injury. Serum PIIINP may therefore provide new and clinically relevant information on the healing of myocardial infarction.",
keywords = "Adult, Aged, Aged, 80 and over, Chromatography, Gel, Female, Heart Aneurysm, Heart Septum, Heart Ventricles, Humans, Male, Middle Aged, Myocardial Infarction, Peptide Fragments, Procollagen, Wound Healing, Case Reports, Journal Article, Research Support, Non-U.S. Gov't",
author = "Jensen, {L T} and K H{\o}rslev-Petersen and P Toft and Bentsen, {K D} and P Grande and Simonsen, {E E} and I Lorenzen",
year = "1990",
month = "1",
language = "English",
volume = "81",
pages = "52--7",
journal = "Circulation. Supplement",
issn = "0009-7322",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction

AU - Jensen, L T

AU - Hørslev-Petersen, K

AU - Toft, P

AU - Bentsen, K D

AU - Grande, P

AU - Simonsen, E E

AU - Lorenzen, I

PY - 1990/1

Y1 - 1990/1

N2 - In 16 patients with acute myocardial infarction and in 15 controls, procollagen type III aminoterminal peptide in serum (PIIINP) was measured consecutively. Serum PIIINP was increased on the second to third postinfarction day (p less than 0.01) and remained elevated for more than 4 months. Peak values were observed on the third to seventh postinfarction day. The individual peak changes were correlated to infarction size calculated from serum CK-MB and serum lactate dehydrogenase (p = 0.60, p = 0.02). The changes in distribution of PIIINP-related antigens in serum after gel chromatography were similar to changes observed during wound healing in humans. PIIINP is cleaved off procollagen type III during the biosynthesis of type III collagen, which characterizes the early stages of repair and inflammation. Our findings suggest that serum PIIINP reflects the repair processes and scar formation following acute myocardial infarction. The serum PIIINP alterations in acute myocardial infarction differ essentially from the changes in myocardial enzymes reflecting myocardial injury. Serum PIIINP may therefore provide new and clinically relevant information on the healing of myocardial infarction.

AB - In 16 patients with acute myocardial infarction and in 15 controls, procollagen type III aminoterminal peptide in serum (PIIINP) was measured consecutively. Serum PIIINP was increased on the second to third postinfarction day (p less than 0.01) and remained elevated for more than 4 months. Peak values were observed on the third to seventh postinfarction day. The individual peak changes were correlated to infarction size calculated from serum CK-MB and serum lactate dehydrogenase (p = 0.60, p = 0.02). The changes in distribution of PIIINP-related antigens in serum after gel chromatography were similar to changes observed during wound healing in humans. PIIINP is cleaved off procollagen type III during the biosynthesis of type III collagen, which characterizes the early stages of repair and inflammation. Our findings suggest that serum PIIINP reflects the repair processes and scar formation following acute myocardial infarction. The serum PIIINP alterations in acute myocardial infarction differ essentially from the changes in myocardial enzymes reflecting myocardial injury. Serum PIIINP may therefore provide new and clinically relevant information on the healing of myocardial infarction.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Chromatography, Gel

KW - Female

KW - Heart Aneurysm

KW - Heart Septum

KW - Heart Ventricles

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Peptide Fragments

KW - Procollagen

KW - Wound Healing

KW - Case Reports

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 2297848

VL - 81

SP - 52

EP - 57

JO - Circulation. Supplement

JF - Circulation. Supplement

SN - 0009-7322

IS - 1

ER -

ID: 168533664