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Serum levels of the interferon-gamma-inducing cytokine interleukin-18 are increased in individuals at high risk of developing type I diabetes

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  • F Nicoletti
  • I Conget
  • R Di Marco
  • A M Speciale
  • R Morìnigo
  • K Bendtzen
  • R Gomis
Interleukin (IL)-18 is a cytokine primarily produced by macrophages and capable of inducing T lymphocyte synthesis of interferon (IFN)-gamma. An up-regulated synthesis of IFN-gamma with consequential Type I cytokine dominance has been repeatedly shown in Type I (insulin-dependent) diabetes mellitus and thought to be involved in its pathogenesis. Because increased production of IFN-gamma could be secondary to a dysregulated synthesis of IL-18, we compared the circulating levels of IL-18 in patients with newly diagnosed Type I diabetes with those of non-diabetic first-degree relatives and healthy control subjects.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind44
Udgave nummer3
Sider (fra-til)309-11
Antal sider3
ISSN0012-186X
StatusUdgivet - 1 mar. 2001

ID: 34101772