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Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

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[reaction: see text] A mild resin-immobilization strategy employing a readily prepared trityl bromide resin for anchoring building blocks via a phenol group has been developed. With N(alpha)-Fmoc-Tyr-OPfp as a starter building block, it was possible to prepare asymmetrically substituted hybrids of spider- and wasp-type polyamine toxins using solid-phase peptide synthesis conditions.
OriginalsprogEngelsk
TidsskriftOrganic Letters
Vol/bind7
Udgave nummer9
Sider (fra-til)1703-6
Antal sider4
ISSN1523-7060
DOI
StatusUdgivet - 2005

ID: 42359494