Forskning ved Københavns Universitet - Københavns Universitet

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Similar five-year outcome with paclitaxel- and sirolimus-eluting coronary stents

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Niels Bligaard
  • Leif Thuesen
  • Kari Saunamäki
  • Per Thayssen
  • Jens Aarøe
  • Hansen, Peter Riis
  • Jens Flensted Lassen
  • Ghita Stephansen
  • Jeppesen, Jørgen
  • Anders Michael Galløe
  • SORT OUT II investigators

OBJECTIVE: Millions of patients were treated with the sirolimus-eluting Cypher™ and the paclitaxel-eluting Taxus™ coronary stents with potential late-occurring increase in event rates. Therefore, the long-term outcome follow-up is of major clinical interest.

DESIGN: In total, 2.098 unselected patients with ST-segment elevation myocardial infarction (STEMI), non-STEMI, stable or unstable angina pectoris were randomized to receive Cypher™ (n = 1.065) or Taxus™ (n = 1.033) stents and were followed for 5 years.

RESULTS: The primary end-point; the composite of cardiac death, myocardial infarction and target vessel revascularization (major adverse cardiac event, MACE), occurred in 467 patients (22.3%); Cypher™ n = 222 (20.8%), Taxus™ n = 245 (23.7%), ns. Definite and probable stent thrombosis occurred in 107 patients (5.1%); Cypher™ n = 51 (4.8%), Taxus™ n = 56 (5.4%), ns. No statistically significant differences were found in the elements of the primary end-point or in other secondary end-points between the two stent groups. After one year, the annual rates of stent thrombosis and MACE remained constant.

CONCLUSIONS: During 5-year follow-up, the Cypher™ and the Taxus™ coronary stents had similar clinical outcome with no signs of increasing rates of adverse events over time.

OriginalsprogEngelsk
TidsskriftScandinavian Cardiovascular Journal
Vol/bind48
Udgave nummer3
Sider (fra-til)148-155
Antal sider8
ISSN1401-7431
DOI
StatusUdgivet - jun. 2014

ID: 137630470