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Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a PET study with nitric oxide and cyclooxygenase inhibition

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Ilkka Heinonen
  • Bengt Saltin
  • Jukka Kemppainen
  • Hannu T Sipilä
  • Vesa Oikonen
  • Pirjo Nuutila
  • Juhani Knuuti
  • Kari Kalliokoski
  • Hellsten, Ylva
The aim of the present study was to determine the effect of nitric oxide and prostanoids on microcirculation and oxygen uptake specifically in the active skeletal muscle by use of positron emission tomography (PET). Healthy males performed 3 five min bouts of light knee-extensor exercise. Skeletal muscle blood flow and oxygen uptake were measured at rest and during the exercise using PET with H(2)O(15) and (15)O(2) during: 1) control conditions; 2) nitric oxide synthase (NOS) inhibition by arterial infusion of L-NMMA and 3) combined NOS and cyclooxygenase (COX) inhibition by arterial infusion of L-NMMA and indomethacin. At rest, inhibition of NOS alone and in combination with indomethacin reduced (P
OriginalsprogEngelsk
TidsskriftAmerican Journal of Physiology: Heart and Circulatory Physiology
Vol/bind300
Udgave nummer4
Sider (fra-til)H1510-H1517
Antal sider8
ISSN0363-6135
DOI
StatusUdgivet - 2011

Bibliografisk note

CURIS 2011 5200 017

ID: 32904790