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Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.

OriginalsprogEngelsk
TidsskriftBone
Vol/bind70
Sider (fra-til)28-36
Antal sider9
ISSN8756-3282
DOI
StatusUdgivet - 2015

ID: 125952700