Forskning ved Københavns Universitet - Københavns Universitet


Small-molecule inhibition of inflammatory β-cell death

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Morten Lundh, S S Scully, T Mandrup-Poulsen, B K Wagner

With the worldwide increase in diabetes prevalence there is a pressing unmet need for novel antidiabetic therapies. Insufficient insulin production due to impaired β-cell function and apoptotic reduction of β-cell mass is a common denominator in the pathogenesis of diabetes. Current treatments are directed at improving insulin sensitivity, and stimulating insulin secretion or replacing the hormone, but do not target progressive apoptotic β-cell loss. Here we review the current development of small-molecule inhibitors designed to rescue β-cells from apoptosis. Several distinct classes of small molecules have been identified that protect β-cells from inflammatory, oxidative and/or metabolically induced apoptosis. Although none of these have yet reached the clinic, β-cell protective small molecules alone or in combination with current therapies provide exciting opportunities for the development of novel treatments for diabetes.
TidsskriftDiabetes, Obesity and Metabolism Online
Udgave nummer3
Sider (fra-til)176-84
Antal sider9
StatusUdgivet - sep. 2013

ID: 77964060