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Small-molecule inhibition of inflammatory β-cell death

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Morten Lundh, S S Scully, T Mandrup-Poulsen, B K Wagner

With the worldwide increase in diabetes prevalence there is a pressing unmet need for novel antidiabetic therapies. Insufficient insulin production due to impaired β-cell function and apoptotic reduction of β-cell mass is a common denominator in the pathogenesis of diabetes. Current treatments are directed at improving insulin sensitivity, and stimulating insulin secretion or replacing the hormone, but do not target progressive apoptotic β-cell loss. Here we review the current development of small-molecule inhibitors designed to rescue β-cells from apoptosis. Several distinct classes of small molecules have been identified that protect β-cells from inflammatory, oxidative and/or metabolically induced apoptosis. Although none of these have yet reached the clinic, β-cell protective small molecules alone or in combination with current therapies provide exciting opportunities for the development of novel treatments for diabetes.
OriginalsprogEngelsk
TidsskriftDiabetes, Obesity and Metabolism Online
Vol/bind15
Udgave nummer3
Sider (fra-til)176-84
Antal sider9
ISSN1463-1326
DOI
StatusUdgivet - sep. 2013

ID: 77964060