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Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT : final results after a 5-year screening programme. / Ashraf, Haseem; Saghir, Zaigham; Dirksen, Asger; Pedersen, Jesper Johannes Holst; Thomsen, Laura Hohwü; Døssing, Martin; Tønnesen, Philip.

I: Thorax, Bind 69, Nr. 6, 06.2014, s. 574-579.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ashraf, H, Saghir, Z, Dirksen, A, Pedersen, JJH, Thomsen, LH, Døssing, M & Tønnesen, P 2014, 'Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme', Thorax, bind 69, nr. 6, s. 574-579. https://doi.org/10.1136/thoraxjnl-2013-203849

APA

Ashraf, H., Saghir, Z., Dirksen, A., Pedersen, J. J. H., Thomsen, L. H., Døssing, M., & Tønnesen, P. (2014). Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme. Thorax, 69(6), 574-579. https://doi.org/10.1136/thoraxjnl-2013-203849

Vancouver

Ashraf H, Saghir Z, Dirksen A, Pedersen JJH, Thomsen LH, Døssing M o.a. Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme. Thorax. 2014 jun;69(6):574-579. https://doi.org/10.1136/thoraxjnl-2013-203849

Author

Ashraf, Haseem ; Saghir, Zaigham ; Dirksen, Asger ; Pedersen, Jesper Johannes Holst ; Thomsen, Laura Hohwü ; Døssing, Martin ; Tønnesen, Philip. / Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT : final results after a 5-year screening programme. I: Thorax. 2014 ; Bind 69, Nr. 6. s. 574-579.

Bibtex

@article{fe841b6cee594743a3e0d4f3d9ee988d,
title = "Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme",
abstract = "BACKGROUND: We present the final results of the effect of lung cancer screening with low-dose CT on the smoking habits of participants in a 5-year screening trial.METHODS: The Danish Lung Cancer Screening Trial (DLCST) was a 5-year screening trial that enrolled 4104 subjects; 2052 were randomised to annual low-dose CT (CT group) and 2052 received no intervention (control group). Participants were current and ex-smokers (≥4 weeks abstinence from smoking) with a tobacco consumption of ≥20 pack years. Smoking habits were determined annually. Missing values for smoking status at the final screening round were handled using two different models.RESULTS: There were no statistically significant differences in annual smoking status between the CT group and control group. Overall the ex-smoker rates (CT + control group) significantly increased from 24{\%} (baseline) to 37{\%} at year 5 of screening (p<0.001). The annual point prevalence quit rate increased from 11{\%} to 24{\%} during the five screening rounds; the ex-smokers' relapse rate remained stable, around 11{\%}, across the same period.CONCLUSIONS: Screening with low-dose CT had no extra effect on smoking status compared with the control group, but overall the screening programme probably promoted smoking cessation.CLINICAL TRIAL REGISTRATION: The DLCST is registered in Clinical Trials.gov Protocol Registration System (identification no. NCT00496977).",
keywords = "Aged, Denmark, Early Detection of Cancer, Female, Humans, Lung Neoplasms, Male, Middle Aged, Motivation, Prevalence, Radiation Dosage, Smoking, Smoking Cessation, Tomography, X-Ray Computed",
author = "Haseem Ashraf and Zaigham Saghir and Asger Dirksen and Pedersen, {Jesper Johannes Holst} and Thomsen, {Laura Hohw{\"u}} and Martin D{\o}ssing and Philip T{\o}nnesen",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",
year = "2014",
month = "6",
doi = "10.1136/thoraxjnl-2013-203849",
language = "English",
volume = "69",
pages = "574--579",
journal = "Thorax",
issn = "0040-6376",
publisher = "B M J Group",
number = "6",

}

RIS

TY - JOUR

T1 - Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT

T2 - final results after a 5-year screening programme

AU - Ashraf, Haseem

AU - Saghir, Zaigham

AU - Dirksen, Asger

AU - Pedersen, Jesper Johannes Holst

AU - Thomsen, Laura Hohwü

AU - Døssing, Martin

AU - Tønnesen, Philip

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2014/6

Y1 - 2014/6

N2 - BACKGROUND: We present the final results of the effect of lung cancer screening with low-dose CT on the smoking habits of participants in a 5-year screening trial.METHODS: The Danish Lung Cancer Screening Trial (DLCST) was a 5-year screening trial that enrolled 4104 subjects; 2052 were randomised to annual low-dose CT (CT group) and 2052 received no intervention (control group). Participants were current and ex-smokers (≥4 weeks abstinence from smoking) with a tobacco consumption of ≥20 pack years. Smoking habits were determined annually. Missing values for smoking status at the final screening round were handled using two different models.RESULTS: There were no statistically significant differences in annual smoking status between the CT group and control group. Overall the ex-smoker rates (CT + control group) significantly increased from 24% (baseline) to 37% at year 5 of screening (p<0.001). The annual point prevalence quit rate increased from 11% to 24% during the five screening rounds; the ex-smokers' relapse rate remained stable, around 11%, across the same period.CONCLUSIONS: Screening with low-dose CT had no extra effect on smoking status compared with the control group, but overall the screening programme probably promoted smoking cessation.CLINICAL TRIAL REGISTRATION: The DLCST is registered in Clinical Trials.gov Protocol Registration System (identification no. NCT00496977).

AB - BACKGROUND: We present the final results of the effect of lung cancer screening with low-dose CT on the smoking habits of participants in a 5-year screening trial.METHODS: The Danish Lung Cancer Screening Trial (DLCST) was a 5-year screening trial that enrolled 4104 subjects; 2052 were randomised to annual low-dose CT (CT group) and 2052 received no intervention (control group). Participants were current and ex-smokers (≥4 weeks abstinence from smoking) with a tobacco consumption of ≥20 pack years. Smoking habits were determined annually. Missing values for smoking status at the final screening round were handled using two different models.RESULTS: There were no statistically significant differences in annual smoking status between the CT group and control group. Overall the ex-smoker rates (CT + control group) significantly increased from 24% (baseline) to 37% at year 5 of screening (p<0.001). The annual point prevalence quit rate increased from 11% to 24% during the five screening rounds; the ex-smokers' relapse rate remained stable, around 11%, across the same period.CONCLUSIONS: Screening with low-dose CT had no extra effect on smoking status compared with the control group, but overall the screening programme probably promoted smoking cessation.CLINICAL TRIAL REGISTRATION: The DLCST is registered in Clinical Trials.gov Protocol Registration System (identification no. NCT00496977).

KW - Aged

KW - Denmark

KW - Early Detection of Cancer

KW - Female

KW - Humans

KW - Lung Neoplasms

KW - Male

KW - Middle Aged

KW - Motivation

KW - Prevalence

KW - Radiation Dosage

KW - Smoking

KW - Smoking Cessation

KW - Tomography, X-Ray Computed

U2 - 10.1136/thoraxjnl-2013-203849

DO - 10.1136/thoraxjnl-2013-203849

M3 - Journal article

C2 - 24443174

VL - 69

SP - 574

EP - 579

JO - Thorax

JF - Thorax

SN - 0040-6376

IS - 6

ER -

ID: 138172469