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SOCS-1 deficiency does not prevent diet-induced insulin resistance

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Obesity is associated with inflammation and increased expression of suppressor of cytokine signaling (SOCS) proteins, which inhibit cytokine and insulin signaling. Thus, reducing SOCS expression could prevent the development of obesity-induced insulin resistance. Using SOCS-1 knockout mice, we investigated the contribution of SOCS-1 in the development of insulin resistance induced by a high-fat diet (HFD). SOCS-1 knockout mice on HFD gained 70% more weight, displayed a 2.3-fold increase in epididymal fat pads mass and increased hepatic lipid content. This was accompanied by increased mRNA expression of leptin and the macrophage marker CD68 in white adipose tissue and of SREBP1c and FAS in liver. HFD also induced hyperglycemia in SOCS-1 deficient mice with impairment of glucose and insulin tolerance tests. Thus, despite the role of SOCS proteins in obesity-related insulin resistance, SOCS-1 deficiency alone is not able to prevent insulin resistance induced by a diet rich in fat.

OriginalsprogEngelsk
TidsskriftBiochemical and Biophysical Research Communications
Vol/bind377
Udgave nummer2
Sider (fra-til)447-52
Antal sider6
ISSN0006-291X
DOI
StatusUdgivet - 12 dec. 2008

    Forskningsområder

  • Animals, DNA-Binding Proteins, Diet, Dietary Fats, Fatty Liver, Gene Expression, Insulin Resistance, Mice, Mice, Knockout, Obesity, Suppressor of Cytokine Signaling Proteins

ID: 143328590