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Solid-phase synthesis of 3-amino-2-pyrazolines

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The development of a solid-phase synthesis of 3-amino-2-pyrazolines is described. Conjugate addition of hydrazines to α,β-unsaturated nitriles followed by cyclization yields 3-amino-2-pyrazolines. Acylation or sulfonation of the free amino-group yields a 24 member library of 3-amino-2- pyrazolines.

OriginalsprogEngelsk
TidsskriftTetrahedron Letters
Vol/bind39
Udgave nummer32
Sider (fra-til)5845-5848
Antal sider4
ISSN0040-4039
DOI
StatusUdgivet - 6 aug. 1998

ID: 131118211