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Solid-state interactions between trimethoprim and parabens

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Solid-state interactions between trimethoprim and the esters of 4-hydroxybenzoic acid (parahydroxybenzoates or parabens) used for anti-microbial preservation are investigated. The formation of a crystalline 1/1 molecular compound between trimethoprim and methyl parahydroxybenzoate is demonstrated by differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy, and solid-state C-13-NMR. Interactions between trimethoprim and 4-hydroxybenzoic acid and its ethyl,propyl and butyl esters were not observed. The nature of the trimethoprim and methyl parahydroxybenzoate intermolecular bonding is discussed briefly.
OriginalsprogUdefineret/Ukendt
TidsskriftSTP pharma sciences
Vol/bind4
Udgave nummer4
Sider (fra-til)292-297
Antal sider6
StatusUdgivet - 1994

    Forskningsområder

  • interactions trimethoprim parabens differential scanning calorimetry c-13-nmr fourier transform infrared spectroscopy 1-1 molecular-compound

ID: 38062149