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Solubilization of water-insoluble nutraceuticals in nonionic microemulsions for water-based use

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  • Nissim Garti
  • Imad Zakharia
  • Aviram Spernath
  • Yaghmur, Anan
  • Abraham Aserin
  • Roy E. Hoffman
  • Lewis Jacobs

Winsor IV water-dilutable food-grade microemulsions based on ethoxylated sorbitan esters, water, (R)-(+)-limonene, ethanol, and propylene glycol have been prepared. Tocopherols and lycopene, two active lipophilic antioxidants, have been solubilized in the water-in-oil, bicontinuous, and oil-in-water microemulsions several times more than the oil (R)-(+)-limonene dissolution capacity. Dilution of the aqueous phase and decrease of the surfactant content strongly affect the solubilization capacity and solubilization efficiency of the microemulsion. Self-diffusion coefficients of the water and the oil in the presence of the solubilizates were correlated to the solubilization capacity, and are indicative of the locus of solubilization of the lycopene in the different microstructures.

OriginalsprogEngelsk
TidsskriftProgress in Colloid and Polymer Science
Vol/bind126
Sider (fra-til)184-189
Antal sider6
ISSN0340-255X
DOI
StatusUdgivet - 13 dec. 2004

ID: 221828929