Forskning ved Københavns Universitet - Københavns Universitet

Forside

Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade. / Wetterslev, J; Jarnvig, I; Jørgensen, L N; Olsen, Niels Vidiendal.

I: Acta Anaesthesiologica Scandinavica, Bind 35, Nr. 5, 07.1991, s. 398-401.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Wetterslev, J, Jarnvig, I, Jørgensen, LN & Olsen, NV 1991, 'Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade', Acta Anaesthesiologica Scandinavica, bind 35, nr. 5, s. 398-401.

APA

Wetterslev, J., Jarnvig, I., Jørgensen, L. N., & Olsen, N. V. (1991). Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade. Acta Anaesthesiologica Scandinavica, 35(5), 398-401.

Vancouver

Wetterslev J, Jarnvig I, Jørgensen LN, Olsen NV. Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade. Acta Anaesthesiologica Scandinavica. 1991 jul;35(5):398-401.

Author

Wetterslev, J ; Jarnvig, I ; Jørgensen, L N ; Olsen, Niels Vidiendal. / Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade. I: Acta Anaesthesiologica Scandinavica. 1991 ; Bind 35, Nr. 5. s. 398-401.

Bibtex

@article{85133c8694004ed89eec30a27b699cbd,
title = "Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade",
abstract = "The effects of a split-dose of atropine sulphate versus a single dose of glycopyrrolate given with neostigmine for the reversal of gallamine-induced neuromuscular blockade were studied in 55 patients undergoing gynaecological surgery. The patients were randomized to receive either a single dose of glycopyrrolate (7 micrograms.kg-1) or two doses of atropine (8 micrograms.kg-1 each), given with an interval of 1 min. There were no differences between the two methods with respect to percentage heart rate changes, salivation or arousal time. Four patients demonstrated cardiac arhythmias in the atropine group, whereas none occurred in the glycopyrrolate group (P less than 0.05). It is concluded that a split-dose of atropine has similar chronotropic effects to a single dose of glycopyrrolate for the reversal of gallamine-induced neuromuscular blockade. However, the finding of a higher incidence of cardiac arrhythmias in the atropine group suggests that this reversal regime should be reserved for patients without cardiac disease.",
keywords = "Adult, Arrhythmias, Cardiac, Atropine, Female, Gallamine Triethiodide, Glycopyrrolate, Heart Rate, Humans, Laparoscopy, Laparotomy, Middle Aged, Neostigmine, Neuromuscular Junction",
author = "J Wetterslev and I Jarnvig and J{\o}rgensen, {L N} and Olsen, {Niels Vidiendal}",
year = "1991",
month = jul,
language = "English",
volume = "35",
pages = "398--401",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade

AU - Wetterslev, J

AU - Jarnvig, I

AU - Jørgensen, L N

AU - Olsen, Niels Vidiendal

PY - 1991/7

Y1 - 1991/7

N2 - The effects of a split-dose of atropine sulphate versus a single dose of glycopyrrolate given with neostigmine for the reversal of gallamine-induced neuromuscular blockade were studied in 55 patients undergoing gynaecological surgery. The patients were randomized to receive either a single dose of glycopyrrolate (7 micrograms.kg-1) or two doses of atropine (8 micrograms.kg-1 each), given with an interval of 1 min. There were no differences between the two methods with respect to percentage heart rate changes, salivation or arousal time. Four patients demonstrated cardiac arhythmias in the atropine group, whereas none occurred in the glycopyrrolate group (P less than 0.05). It is concluded that a split-dose of atropine has similar chronotropic effects to a single dose of glycopyrrolate for the reversal of gallamine-induced neuromuscular blockade. However, the finding of a higher incidence of cardiac arrhythmias in the atropine group suggests that this reversal regime should be reserved for patients without cardiac disease.

AB - The effects of a split-dose of atropine sulphate versus a single dose of glycopyrrolate given with neostigmine for the reversal of gallamine-induced neuromuscular blockade were studied in 55 patients undergoing gynaecological surgery. The patients were randomized to receive either a single dose of glycopyrrolate (7 micrograms.kg-1) or two doses of atropine (8 micrograms.kg-1 each), given with an interval of 1 min. There were no differences between the two methods with respect to percentage heart rate changes, salivation or arousal time. Four patients demonstrated cardiac arhythmias in the atropine group, whereas none occurred in the glycopyrrolate group (P less than 0.05). It is concluded that a split-dose of atropine has similar chronotropic effects to a single dose of glycopyrrolate for the reversal of gallamine-induced neuromuscular blockade. However, the finding of a higher incidence of cardiac arrhythmias in the atropine group suggests that this reversal regime should be reserved for patients without cardiac disease.

KW - Adult

KW - Arrhythmias, Cardiac

KW - Atropine

KW - Female

KW - Gallamine Triethiodide

KW - Glycopyrrolate

KW - Heart Rate

KW - Humans

KW - Laparoscopy

KW - Laparotomy

KW - Middle Aged

KW - Neostigmine

KW - Neuromuscular Junction

M3 - Journal article

C2 - 1832261

VL - 35

SP - 398

EP - 401

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 5

ER -

ID: 47240946