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Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins

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  • Erlendsson, Simon
  • Dustin R Morado
  • Harrison B Cullen
  • Cedric Feschotte
  • Jason D Shepherd
  • John A G Briggs

Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.

OriginalsprogEngelsk
TidsskriftNature Neuroscience
Vol/bind23
Sider (fra-til)172-175
ISSN1097-6256
DOI
StatusUdgivet - 2020
Eksternt udgivetJa

ID: 233730523