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Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • G. Andersen
  • J. Overgaard
  • Albrechtsen, Anders
  • C. Glümer
  • K. Borch-Johnsen
  • T. Jørgensen
  • T. Hansen
  • O. Pedersen
The 825C>T polymorphism in the gene encoding the G protein beta3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind49
Udgave nummer1
Sider (fra-til)75-82
Antal sider8
ISSN0012-186X
DOI
StatusUdgivet - 2006
Eksternt udgivetJa

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