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Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus

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Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind44
Udgave nummer2
Sider (fra-til)237-240
Antal sider4
ISSN0012-186X
DOI
StatusUdgivet - feb. 2001

ID: 96264