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Study of medication-free children with Tourette syndrome do not show imaging abnormalities

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

BACKGROUND: Imaging studies of patients with Tourette's syndrome (TS) across different cohorts have shown alterations in gray and white matter in areas associated with the cortico-striato-thalamic-cortical (CSTC) pathways; however, no consistent findings have subsequently established a clear indication of the pathophysiology of TS.

METHODS: This study was designed to investigate changes in gray and white matter in medication-free children with TS in the CSTC areas. With MRI, 24 children with TS and 18 healthy controls were analyzed using three complementary methods.

RESULTS AND CONCLUSION: Analyses revealed no differences between controls and patients with TS in gray or white matter. Possible discrepancies between cohorts and methods may play a role in the different findings in other studies. Further studies investigating well-defined cohorts with TS analyzing both gray and white matter in the same cohort may add additional information to the pathophysiology of TS.

OriginalsprogEngelsk
TidsskriftMovement Disorders
Vol/bind29
Udgave nummer9
Sider (fra-til)1212-1216
Antal sider5
ISSN0885-3185
DOI
StatusUdgivet - aug. 2014

ID: 138376689