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Subchronic toxicity study of peppermint oil in rats

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Peppermint oil was given p.o. to four groups of 28 rats at dosage levels of 0, 10, 40, and 100 mg/kg source body wt. per day for 90 days. At the highest dose histopathological changes consisting of cyst-like spaces scatered in the white matter of cerebellum were seen. No other signs of encephalopathy were observed. Nephropathy was seen in the male rats in the highest dose group. A no-observed-adverse-effect level of 40 mg/kg body wt. per day was determined.
OriginalsprogEngelsk
ArtikelnummerVolume 62, Issues 2–3, September 1992
TidsskriftToxicology Letters
Vol/bind62
Udgave nummer2-3
Sider (fra-til)215-220
Antal sider6
ISSN0378-4274
StatusUdgivet - sep. 1992
Eksternt udgivetJa

ID: 90454816