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Sudden cardiac death and coronary disease in the young: A nationwide cohort study in Denmark

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Sudden cardiac death and coronary disease in the young : A nationwide cohort study in Denmark. / Zachariasardóttir, Sára; Risgaard, Bjarke; Ågesen, Frederik Nybye; Jabbari, Reza; Glinge, Charlotte; Ingemann-Hansen, Ole; Ottesen, Gyda Lolk; Thomsen, Jørgen Lange; Haunsø, Stig; Banner, Jytte; Winkel, Bo Gregers; Tfelt-Hansen, Jacob.

I: International Journal of Cardiology, Bind 236, Nr. 1, 2017, s. 16-22.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Zachariasardóttir, S, Risgaard, B, Ågesen, FN, Jabbari, R, Glinge, C, Ingemann-Hansen, O, Ottesen, GL, Thomsen, JL, Haunsø, S, Banner, J, Winkel, BG & Tfelt-Hansen, J 2017, 'Sudden cardiac death and coronary disease in the young: A nationwide cohort study in Denmark', International Journal of Cardiology, bind 236, nr. 1, s. 16-22. https://doi.org/10.1016/j.ijcard.2017.01.118

APA

Zachariasardóttir, S., Risgaard, B., Ågesen, F. N., Jabbari, R., Glinge, C., Ingemann-Hansen, O., ... Tfelt-Hansen, J. (2017). Sudden cardiac death and coronary disease in the young: A nationwide cohort study in Denmark. International Journal of Cardiology, 236(1), 16-22. https://doi.org/10.1016/j.ijcard.2017.01.118

Vancouver

Zachariasardóttir S, Risgaard B, Ågesen FN, Jabbari R, Glinge C, Ingemann-Hansen O o.a. Sudden cardiac death and coronary disease in the young: A nationwide cohort study in Denmark. International Journal of Cardiology. 2017;236(1):16-22. https://doi.org/10.1016/j.ijcard.2017.01.118

Author

Zachariasardóttir, Sára ; Risgaard, Bjarke ; Ågesen, Frederik Nybye ; Jabbari, Reza ; Glinge, Charlotte ; Ingemann-Hansen, Ole ; Ottesen, Gyda Lolk ; Thomsen, Jørgen Lange ; Haunsø, Stig ; Banner, Jytte ; Winkel, Bo Gregers ; Tfelt-Hansen, Jacob. / Sudden cardiac death and coronary disease in the young : A nationwide cohort study in Denmark. I: International Journal of Cardiology. 2017 ; Bind 236, Nr. 1. s. 16-22.

Bibtex

@article{a7160aa79e504eb4ab5906f5a93656e2,
title = "Sudden cardiac death and coronary disease in the young: A nationwide cohort study in Denmark",
abstract = "BACKGROUND: Sudden cardiac death caused by coronary artery disease (CAD-SCD) is the most frequent cause of SCD in persons <50years. The aim of this study was to examine differences in clinical characteristics and autopsy findings of the heart among 18-35 and 36-49year old CAD-SCD cases.METHODS: We have previously identified all sudden cardiac deaths in Denmark through review of death certificates and autopsy reports including all deaths between 2000 and 2006 in individuals aged 18-35years and all deaths between 2007 and 2009 in individuals aged 18-49years. In this study we included the 197 autopsied CAD-SCD cases. Full autopsy report and medical records from general practitioners and hospitals were obtained.RESULTS: There was a male predominance (n=151, 76{\%}) and the median age was 42years. In witnessed cases, 51{\%} had a shockable rhythm and 9 cases returned to spontaneous circulation briefly, CAD-SCD victims aged 36-49years had more severe atherosclerosis in all coronary arteries, more multi-vessel disease (29{\%} vs. 15{\%}, p=0.049) and less commonly (38{\%} vs. 54{\%}, p=0.039) acute coronary occlusion than victims <36years. Sixty-eight percent(n=133) of CAD-SCD victims had cardiac symptoms prior to death.CONCLUSION: This nationwide study found several differences in the pathologic lesions of the heart in victims aged 18-35 and 36-49years, which might be associated with different disease progression leading to death in these age groups. We also report a high frequency of cardiac symptoms prior to death in young CAD-SCD cases, which may enable clinicians to prevent these tragic deaths.",
keywords = "Journal Article",
author = "S{\'a}ra Zachariasard{\'o}ttir and Bjarke Risgaard and {\AA}gesen, {Frederik Nybye} and Reza Jabbari and Charlotte Glinge and Ole Ingemann-Hansen and Ottesen, {Gyda Lolk} and Thomsen, {J{\o}rgen Lange} and Stig Hauns{\o} and Jytte Banner and Winkel, {Bo Gregers} and Jacob Tfelt-Hansen",
note = "Copyright {\circledC} 2017 Elsevier Ireland Ltd. All rights reserved.",
year = "2017",
doi = "10.1016/j.ijcard.2017.01.118",
language = "English",
volume = "236",
pages = "16--22",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Sudden cardiac death and coronary disease in the young

T2 - A nationwide cohort study in Denmark

AU - Zachariasardóttir, Sára

AU - Risgaard, Bjarke

AU - Ågesen, Frederik Nybye

AU - Jabbari, Reza

AU - Glinge, Charlotte

AU - Ingemann-Hansen, Ole

AU - Ottesen, Gyda Lolk

AU - Thomsen, Jørgen Lange

AU - Haunsø, Stig

AU - Banner, Jytte

AU - Winkel, Bo Gregers

AU - Tfelt-Hansen, Jacob

N1 - Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Sudden cardiac death caused by coronary artery disease (CAD-SCD) is the most frequent cause of SCD in persons <50years. The aim of this study was to examine differences in clinical characteristics and autopsy findings of the heart among 18-35 and 36-49year old CAD-SCD cases.METHODS: We have previously identified all sudden cardiac deaths in Denmark through review of death certificates and autopsy reports including all deaths between 2000 and 2006 in individuals aged 18-35years and all deaths between 2007 and 2009 in individuals aged 18-49years. In this study we included the 197 autopsied CAD-SCD cases. Full autopsy report and medical records from general practitioners and hospitals were obtained.RESULTS: There was a male predominance (n=151, 76%) and the median age was 42years. In witnessed cases, 51% had a shockable rhythm and 9 cases returned to spontaneous circulation briefly, CAD-SCD victims aged 36-49years had more severe atherosclerosis in all coronary arteries, more multi-vessel disease (29% vs. 15%, p=0.049) and less commonly (38% vs. 54%, p=0.039) acute coronary occlusion than victims <36years. Sixty-eight percent(n=133) of CAD-SCD victims had cardiac symptoms prior to death.CONCLUSION: This nationwide study found several differences in the pathologic lesions of the heart in victims aged 18-35 and 36-49years, which might be associated with different disease progression leading to death in these age groups. We also report a high frequency of cardiac symptoms prior to death in young CAD-SCD cases, which may enable clinicians to prevent these tragic deaths.

AB - BACKGROUND: Sudden cardiac death caused by coronary artery disease (CAD-SCD) is the most frequent cause of SCD in persons <50years. The aim of this study was to examine differences in clinical characteristics and autopsy findings of the heart among 18-35 and 36-49year old CAD-SCD cases.METHODS: We have previously identified all sudden cardiac deaths in Denmark through review of death certificates and autopsy reports including all deaths between 2000 and 2006 in individuals aged 18-35years and all deaths between 2007 and 2009 in individuals aged 18-49years. In this study we included the 197 autopsied CAD-SCD cases. Full autopsy report and medical records from general practitioners and hospitals were obtained.RESULTS: There was a male predominance (n=151, 76%) and the median age was 42years. In witnessed cases, 51% had a shockable rhythm and 9 cases returned to spontaneous circulation briefly, CAD-SCD victims aged 36-49years had more severe atherosclerosis in all coronary arteries, more multi-vessel disease (29% vs. 15%, p=0.049) and less commonly (38% vs. 54%, p=0.039) acute coronary occlusion than victims <36years. Sixty-eight percent(n=133) of CAD-SCD victims had cardiac symptoms prior to death.CONCLUSION: This nationwide study found several differences in the pathologic lesions of the heart in victims aged 18-35 and 36-49years, which might be associated with different disease progression leading to death in these age groups. We also report a high frequency of cardiac symptoms prior to death in young CAD-SCD cases, which may enable clinicians to prevent these tragic deaths.

KW - Journal Article

U2 - 10.1016/j.ijcard.2017.01.118

DO - 10.1016/j.ijcard.2017.01.118

M3 - Journal article

C2 - 28202258

VL - 236

SP - 16

EP - 22

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 1

ER -

ID: 173707468