Forskning ved Københavns Universitet - Københavns Universitet

Forside

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways. / Karlsen, Allan Ertman; Heding, P E; Frobøse, H; Rønn, S G; Kruhøffer, M; Orntoft, T F; Darville, M; Eizirik, D L; Pociot, F; Nerup, J; Mandrup-Poulsen, Thomas; Billestrup, N.

I: Diabetologia, Bind 47, Nr. 11, 01.11.2004, s. 1998-2011.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Karlsen, AE, Heding, PE, Frobøse, H, Rønn, SG, Kruhøffer, M, Orntoft, TF, Darville, M, Eizirik, DL, Pociot, F, Nerup, J, Mandrup-Poulsen, T & Billestrup, N 2004, 'Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways', Diabetologia, bind 47, nr. 11, s. 1998-2011. https://doi.org/10.1007/s00125-004-1568-3

APA

Karlsen, A. E., Heding, P. E., Frobøse, H., Rønn, S. G., Kruhøffer, M., Orntoft, T. F., ... Billestrup, N. (2004). Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways. Diabetologia, 47(11), 1998-2011. https://doi.org/10.1007/s00125-004-1568-3

Vancouver

Karlsen AE, Heding PE, Frobøse H, Rønn SG, Kruhøffer M, Orntoft TF o.a. Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways. Diabetologia. 2004 nov 1;47(11):1998-2011. https://doi.org/10.1007/s00125-004-1568-3

Author

Karlsen, Allan Ertman ; Heding, P E ; Frobøse, H ; Rønn, S G ; Kruhøffer, M ; Orntoft, T F ; Darville, M ; Eizirik, D L ; Pociot, F ; Nerup, J ; Mandrup-Poulsen, Thomas ; Billestrup, N. / Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways. I: Diabetologia. 2004 ; Bind 47, Nr. 11. s. 1998-2011.

Bibtex

@article{38bd4edfcd4a45a1807827e4761d9eb7,
title = "Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways",
abstract = "The proinflammatory cytokine IL-1beta induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback regulator of IL-1beta- and IFN-gamma-mediated signalling in rat islets and beta cell lines, preventing their deleterious effects. However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown.",
keywords = "Animals, Apoptosis, Base Sequence, Cell Line, DNA Primers, Gene Expression Regulation, Interleukin-1, NF-kappa B, Nitric Oxide, Oligonucleotide Array Sequence Analysis, Rats, Repressor Proteins, Signal Transduction, Suppressor of Cytokine Signaling Proteins, Transcription Factors",
author = "Karlsen, {Allan Ertman} and Heding, {P E} and H Frob{\o}se and R{\o}nn, {S G} and M Kruh{\o}ffer and Orntoft, {T F} and M Darville and Eizirik, {D L} and F Pociot and J Nerup and Thomas Mandrup-Poulsen and N Billestrup",
year = "2004",
month = "11",
day = "1",
doi = "10.1007/s00125-004-1568-3",
language = "English",
volume = "47",
pages = "1998--2011",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "11",

}

RIS

TY - JOUR

T1 - Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

AU - Karlsen, Allan Ertman

AU - Heding, P E

AU - Frobøse, H

AU - Rønn, S G

AU - Kruhøffer, M

AU - Orntoft, T F

AU - Darville, M

AU - Eizirik, D L

AU - Pociot, F

AU - Nerup, J

AU - Mandrup-Poulsen, Thomas

AU - Billestrup, N

PY - 2004/11/1

Y1 - 2004/11/1

N2 - The proinflammatory cytokine IL-1beta induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback regulator of IL-1beta- and IFN-gamma-mediated signalling in rat islets and beta cell lines, preventing their deleterious effects. However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown.

AB - The proinflammatory cytokine IL-1beta induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback regulator of IL-1beta- and IFN-gamma-mediated signalling in rat islets and beta cell lines, preventing their deleterious effects. However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown.

KW - Animals

KW - Apoptosis

KW - Base Sequence

KW - Cell Line

KW - DNA Primers

KW - Gene Expression Regulation

KW - Interleukin-1

KW - NF-kappa B

KW - Nitric Oxide

KW - Oligonucleotide Array Sequence Analysis

KW - Rats

KW - Repressor Proteins

KW - Signal Transduction

KW - Suppressor of Cytokine Signaling Proteins

KW - Transcription Factors

U2 - 10.1007/s00125-004-1568-3

DO - 10.1007/s00125-004-1568-3

M3 - Journal article

C2 - 15578154

VL - 47

SP - 1998

EP - 2011

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 11

ER -

ID: 33902540