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Synthesis and application of a new fluorous-tagged ammonia equivalent

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A novel fluorous-tagged ammonia equivalent has been developed. It is based on a nitrogen-oxygen bond, which can be cleaved in a traceless manner by a molybdenum complex or samarium diiodide. The application in the synthesis of ureas, amides, sulfonamides, and carbamates is described. The scope of the fluorous N--O linker is exemplified by the synthesis of itopride, a drug used for the treatment of functional dyspepsia. Itopride was synthesized with the aid of fluorous purification methods and the product was isolated in good overall yield, with high purity.
OriginalsprogEngelsk
TidsskriftChemistry: A European Journal
Vol/bind16
Udgave nummer15
Sider (fra-til)4557-4566
ISSN0947-6539
DOI
StatusUdgivet - 2010

ID: 19345237