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Synthesis of the thapsigargins

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Steven V. Ley
  • Alessandra Antonello
  • Emily P. Balskus
  • David T. Booth
  • Christensen, Søren Brøgger
  • Ed Cleator
  • Helen Gold
  • Klemens Högenauer
  • Udo Hünger
  • Rebecca M. Myers
  • Steven F. Oliver
  • Oliver Simic
  • Martin D. Smith
  • Helmer Søhoel
  • Alison J.A. Woolford

The thapsigargins are a family of complex guaianolides with potent and selective Ca2+-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.

OriginalsprogEngelsk
TidsskriftProceedings of the National Academy of Sciences of the United States of America
Vol/bind101
Udgave nummer33
Sider (fra-til)12073-12078
Antal sider6
ISSN0027-8424
DOI
StatusUdgivet - 17 aug. 2004

ID: 232596272