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Synthesis, structural characterization and cytotoxic activity against tumor cells of heteroleptic copper (I) complexes with aromatic diimines and phosphines

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Natalia Alvarez
  • Carolina Noble
  • María H. Torre
  • Eduardo Kremer
  • Javier Ellena
  • Marcio Peres de Araujo
  • Antonio J. Costa-Filho
  • Luis Felipe Mendes
  • M. Gabriela Kramer
  • Gianella Facchin
Copper coordination complexes are increasingly recognized as potential drugs for therapeutic use in various diseases, especially in cancer. In an attempt to find new leaders for the development of antitumor Cu compounds, heteroleptic Cu(I)
complexes with triphenylphosphine (PPh3) and dimethylbipyridine (dmbpy),
phenanthroline (phen) or neocuproine (neo) were prepared and characterized. The compounds [CuCl(dmbpy)(PPh3)] (1), [CuCl(phen)(PPh3)]0,25H2O (2) and
[CuCl(neo)(PPh3)] (3) were obtained. The crystal structures of compounds 2 and 3 were determined. In both complexes, the Cu(I) centre presents distorted tetrahedral coordination. All complexes present cytotoxic activity, against tumor cell lines, being more active than Cisplatin, with IC50 in the low micromolar range. This activity augments in the order 123, following the same order as the lipophilicity.
OriginalsprogEngelsk
TidsskriftInorganica Chimica Acta
ISSN0020-1693
DOI
StatusUdgivet - 21 jun. 2017
Eksternt udgivetJa

ID: 180364200