Forskning ved Københavns Universitet - Københavns Universitet

Forside

Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex: Secondary analysis of the DALI study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Rodrigo A. Lima
  • Gernot Desoye
  • David Simmons
  • Roland Devlieger
  • Sander Galjaard
  • Rosa Corcoy
  • Juan M. Adelantado
  • Fidelma Dunne
  • Jürgen Harreiter
  • Alexandra Kautzky-Willer
  • Dorte M. Jensen
  • Lise Lotte Andersen
  • Mette Tanvig
  • Annunziata Lapolla
  • Maria G. Dalfra
  • Alessandra Bertolotto
  • Ewa Wender-Ozegowska
  • Agnieszka Zawiejska
  • David J. Hill
  • Frank J. Snoek
  • Judith G.M. Jelsma
  • Mireille N.M. van Poppel

Objectives: To investigate the importance of time in pregnancy and neonatal sex on the association between maternal metabolic parameters and neonatal sum of skinfolds. Methods: This was a longitudinal, secondary analysis of the vitamin D and lifestyle intervention for gestational diabetes mellitus study, conducted in nine European countries during 2012 to 2015. Pregnant women with a pre-pregnancy body mass index (BMI) of ≥29 kg/m2 were invited to participate. We measured 14 maternal metabolic parameters at three times during pregnancy: <20 weeks, 24 to 28 weeks, and 35 to 37 weeks of gestation. The sum of four skinfolds assessed within 2 days after birth was the measure of neonatal adiposity. Results: In total, 458 mother-infant pairs (50.2% female infants) were included. Insulin resistance (fasting insulin and HOMA-index of insulin resistance) in early pregnancy was an important predictor for boys' sum of skinfolds, in addition to fasting glucose and maternal adiposity (leptin, BMI and neck circumference) throughout pregnancy. In girls, maternal lipids (triglycerides and fatty acids) in the first half of pregnancy were important predictors of sum of skinfolds, as well as fasting glucose in the second half of pregnancy. Conclusions: Associations between maternal metabolic parameters and neonatal adiposity vary between different periods during pregnancy. This time-dependency is different between sexes, suggesting different growth strategies.

OriginalsprogEngelsk
Artikelnummere12628
TidsskriftPediatric Obesity
Vol/bind15
Udgave nummer7
Antal sider11
ISSN2047-6302
DOI
StatusUdgivet - jul. 2020

ID: 244325617