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The combination of etanercept and methotrexate increases the effectiveness of treatment in active psoriasis despite inadequate effect of methotrexate therapy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Zachariae, Claus
  • N.J. Mork
  • T. Reunala
  • H. Lorentzen
  • E. Falk
  • S.L. Karvonen
  • A. Johannesson
  • B. Clareus
  • L. Skov
  • G. Mork
  • S. Walker
  • S. Qvitzau
Many patients with moderate-to-severe plaque psoriasis do not respond adequately to methotrexate monotherapy. This pilot study, with a small patient population, was performed to evaluate the effectiveness and safety of etanercept and methotrexate combination in patients with plaque psoriasis and inadequate response to methotrexate. Outpatients with plaque psoriasis (Psoriasis Area and Severity Index >= 8 and/or body surface area > 10%), despite methotrexate treatment (>= 3 months; >= 7.5 mg/ week) were randomized to either etanercept with methotrexate tapered and discontinued (n = 28) or etanercept with continuous methotrexate (n = 31). Significantly more patients had a Physicians' Global Assessment of "clear"/"almost clear" in the combination group compared with etanercept/methotrexate taper (66.7 vs. 37.0%, respectively; p = 0.025). Adverse events were similar for both groups, with no cases of tuberculosis, malignancies or opportunistic infections reported. Addition of etanercept to methotrexate achieved significant improvement in psoriasis after 24 weeks
Udgivelsesdato: 2008
OriginalsprogEngelsk
TidsskriftActa Dermato Venereologica
Vol/bind88
Udgave nummer5
Sider (fra-til)495-501
Antal sider6
ISSN0001-5555
StatusUdgivet - 2008

Bibliografisk note

Times Cited: 0ArticleEnglishZachariae, CCopenhagen Univ Hosp, Dept Dermatol, Niels Andersensvej 65, DK-2900 Hellerup, DenmarkCited References Count: 28353KVACTA DERMATO-VENEREOLOGICATRADGARDSGATAN 14, UPPSALA, SE-753 09, SWEDENUPPSALA

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