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The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • J.M. Bahl
  • N.H. Heegaard
  • G. Falkenhorst
  • H. Laursen
  • H. Hogenhaven
  • K. Molbak
  • C. Jespersgaard
  • L. Hougs
  • Waldemar, Gunhild
  • P. Johannsen
  • M. Christiansen
Laboratory markers have a prominent place among the diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Here we investigate the capability of protein 14-3-3, total-tau (t-tau), threonin-181-phosphorylated tau (p-tau), and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) together with the prion protein gene genotype to discriminate patients with sCJD (n=21) from neurological controls (n=164) and Alzheimer's disease (AD) patients (n=49). Low p-tau/t-tau ratio was the best single marker for sCJD with 90% specificity against neurological controls at 86% sensitivity whilst NSE was the least accurate with 79% sensitivity at 90% specificity. Many of the sCJD patients had extremely elevated t-tau values but normal values of the AD-marker p-tau. Protein 14-3-3 was very sensitive (95%) although the specificity was relatively low (75%). A combination of elevated t-tau concentration with the presence of 14-3-3 protein in CSF gave the best test specificity of 96% at 84% sensitivity. We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias
Udgivelsesdato: 2009/11
OriginalsprogEngelsk
TidsskriftNeurobiology of Aging
Vol/bind30
Udgave nummer11
Sider (fra-til)1834-1841
Antal sider8
ISSN0197-4580
DOI
StatusUdgivet - 2009

ID: 19793362