Forskning ved Københavns Universitet - Københavns Universitet

Forside

The effect of intravenous omeprazole on the gastric and duodenal potential difference and pH in healthy subjects

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

The effect of intravenous omeprazole (40 and 80 mg) on the gastric and duodenal potential difference (PD) and pH was investigated in 9 healthy volunteers. Gastric PD and pH increased significantly (p < 0.05) following omeprazole, and the increases were equal following the two doses. No changes were found in duodenal PD or pH. It has been claimed that gastric PD changes following acid secretion inhibition with cimetidine and glucagon might be due to changes in the parietal cell surface area. Omeprazole causes no changes in the parietal cell structure, and the changes in gastric PD following omeprazole might therefore be ascribed to changes in mucosal electrophysiologic transport or resistance.

OriginalsprogEngelsk
TidsskriftDigestion
Vol/bind54
Udgave nummer1
Sider (fra-til)15-8
Antal sider4
ISSN0012-2823
StatusUdgivet - 1993

ID: 165884732