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The effect of introducing pelvic lymphadenectomy on survival and recurrence rates in Danish endometrial cancer patients at high risk: A Danish Gynecological Cancer Group study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

The effect of introducing pelvic lymphadenectomy on survival and recurrence rates in Danish endometrial cancer patients at high risk : A Danish Gynecological Cancer Group study. / Ørtoft, Gitte; Høgdall, Claus; Juhl, Caroline; Petersen, Lone K.; Hansen, Estrid S.; Dueholm, Margit.

I: International Journal of Gynecological Cancer, Bind 29, Nr. 1, 2019, s. 68-76.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ørtoft, G, Høgdall, C, Juhl, C, Petersen, LK, Hansen, ES & Dueholm, M 2019, 'The effect of introducing pelvic lymphadenectomy on survival and recurrence rates in Danish endometrial cancer patients at high risk: A Danish Gynecological Cancer Group study', International Journal of Gynecological Cancer, bind 29, nr. 1, s. 68-76. https://doi.org/10.1136/ijgc-2018-000023

APA

Ørtoft, G., Høgdall, C., Juhl, C., Petersen, L. K., Hansen, E. S., & Dueholm, M. (2019). The effect of introducing pelvic lymphadenectomy on survival and recurrence rates in Danish endometrial cancer patients at high risk: A Danish Gynecological Cancer Group study. International Journal of Gynecological Cancer, 29(1), 68-76. https://doi.org/10.1136/ijgc-2018-000023

Vancouver

Ørtoft G, Høgdall C, Juhl C, Petersen LK, Hansen ES, Dueholm M. The effect of introducing pelvic lymphadenectomy on survival and recurrence rates in Danish endometrial cancer patients at high risk: A Danish Gynecological Cancer Group study. International Journal of Gynecological Cancer. 2019;29(1):68-76. https://doi.org/10.1136/ijgc-2018-000023

Author

Ørtoft, Gitte ; Høgdall, Claus ; Juhl, Caroline ; Petersen, Lone K. ; Hansen, Estrid S. ; Dueholm, Margit. / The effect of introducing pelvic lymphadenectomy on survival and recurrence rates in Danish endometrial cancer patients at high risk : A Danish Gynecological Cancer Group study. I: International Journal of Gynecological Cancer. 2019 ; Bind 29, Nr. 1. s. 68-76.

Bibtex

@article{d9f55336cdc6491ea48911280a85a014,
title = "The effect of introducing pelvic lymphadenectomy on survival and recurrence rates in Danish endometrial cancer patients at high risk: A Danish Gynecological Cancer Group study",
abstract = "Objectives To evaluate the rate of survival and recurrence related to the introduction of pelvic lymphadenectomy in Danish high-risk endometrial cancer patients. Study design Data on 713 high-risk patients defined as grade 3 with >50{\%} myometrial invasion or serous/clear/undifferentiated carcinomas stage I-IV endometrial cancer patients diagnosed from 2005 to 2012 were retrieved from the Danish Gynecological Cancer Database. Of these, 305 were high-risk stage I. Five year Kaplan-Meier survival estimates and actuarial recurrence rates were calculated, and adjusted Cox used for comparison. Findings were compared with earlier Danish results. Results Lymphadenectomy in 390 radically operated high-risk patients resulted in upstaging of 31 patients from stage I to IIIC and 19 patients from stage II to IIIC corresponding to 12.8{\%}. Upstaging from stage I to IIIC had a cancer-specific survival of 77{\%}, almost comparable to lymph node-negative high-risk stage I patients (81{\%}). Lymphadenectomy patients had a significant higher overall survival as compared with non-lymph node resected for all patients, but not for stage I patients. Lymphadenectomy, however, did not significantly affect cancer-specific survival, progression-free survival, recurrence rate or risk of local, distant, or lymph node recurrence. When the survival of high-risk stage I patients was compared with earlier Danish results, a small improvement in overall survival (7{\%}) and cancer-specificsurvival (8{\%}) was demonstrated. Conclusion Only a small number of high-risk patients were upstaged from stage I to III due to lymphadenectomy. These patients showed a surprisingly good survival possibly due to correct stage identification and subsequent relevant adjuvant therapy. However, even though introduction of lymphadenectomy in the Danish high-risk population seems to increase overall survival, no significant change in cancer-specific survival, progression-free survival or recurrence patterns was demonstrated.",
author = "Gitte {\O}rtoft and Claus H{\o}gdall and Caroline Juhl and Petersen, {Lone K.} and Hansen, {Estrid S.} and Margit Dueholm",
year = "2019",
doi = "10.1136/ijgc-2018-000023",
language = "English",
volume = "29",
pages = "68--76",
journal = "International Journal of Gynecological Cancer",
issn = "1048-891X",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - The effect of introducing pelvic lymphadenectomy on survival and recurrence rates in Danish endometrial cancer patients at high risk

T2 - A Danish Gynecological Cancer Group study

AU - Ørtoft, Gitte

AU - Høgdall, Claus

AU - Juhl, Caroline

AU - Petersen, Lone K.

AU - Hansen, Estrid S.

AU - Dueholm, Margit

PY - 2019

Y1 - 2019

N2 - Objectives To evaluate the rate of survival and recurrence related to the introduction of pelvic lymphadenectomy in Danish high-risk endometrial cancer patients. Study design Data on 713 high-risk patients defined as grade 3 with >50% myometrial invasion or serous/clear/undifferentiated carcinomas stage I-IV endometrial cancer patients diagnosed from 2005 to 2012 were retrieved from the Danish Gynecological Cancer Database. Of these, 305 were high-risk stage I. Five year Kaplan-Meier survival estimates and actuarial recurrence rates were calculated, and adjusted Cox used for comparison. Findings were compared with earlier Danish results. Results Lymphadenectomy in 390 radically operated high-risk patients resulted in upstaging of 31 patients from stage I to IIIC and 19 patients from stage II to IIIC corresponding to 12.8%. Upstaging from stage I to IIIC had a cancer-specific survival of 77%, almost comparable to lymph node-negative high-risk stage I patients (81%). Lymphadenectomy patients had a significant higher overall survival as compared with non-lymph node resected for all patients, but not for stage I patients. Lymphadenectomy, however, did not significantly affect cancer-specific survival, progression-free survival, recurrence rate or risk of local, distant, or lymph node recurrence. When the survival of high-risk stage I patients was compared with earlier Danish results, a small improvement in overall survival (7%) and cancer-specificsurvival (8%) was demonstrated. Conclusion Only a small number of high-risk patients were upstaged from stage I to III due to lymphadenectomy. These patients showed a surprisingly good survival possibly due to correct stage identification and subsequent relevant adjuvant therapy. However, even though introduction of lymphadenectomy in the Danish high-risk population seems to increase overall survival, no significant change in cancer-specific survival, progression-free survival or recurrence patterns was demonstrated.

AB - Objectives To evaluate the rate of survival and recurrence related to the introduction of pelvic lymphadenectomy in Danish high-risk endometrial cancer patients. Study design Data on 713 high-risk patients defined as grade 3 with >50% myometrial invasion or serous/clear/undifferentiated carcinomas stage I-IV endometrial cancer patients diagnosed from 2005 to 2012 were retrieved from the Danish Gynecological Cancer Database. Of these, 305 were high-risk stage I. Five year Kaplan-Meier survival estimates and actuarial recurrence rates were calculated, and adjusted Cox used for comparison. Findings were compared with earlier Danish results. Results Lymphadenectomy in 390 radically operated high-risk patients resulted in upstaging of 31 patients from stage I to IIIC and 19 patients from stage II to IIIC corresponding to 12.8%. Upstaging from stage I to IIIC had a cancer-specific survival of 77%, almost comparable to lymph node-negative high-risk stage I patients (81%). Lymphadenectomy patients had a significant higher overall survival as compared with non-lymph node resected for all patients, but not for stage I patients. Lymphadenectomy, however, did not significantly affect cancer-specific survival, progression-free survival, recurrence rate or risk of local, distant, or lymph node recurrence. When the survival of high-risk stage I patients was compared with earlier Danish results, a small improvement in overall survival (7%) and cancer-specificsurvival (8%) was demonstrated. Conclusion Only a small number of high-risk patients were upstaged from stage I to III due to lymphadenectomy. These patients showed a surprisingly good survival possibly due to correct stage identification and subsequent relevant adjuvant therapy. However, even though introduction of lymphadenectomy in the Danish high-risk population seems to increase overall survival, no significant change in cancer-specific survival, progression-free survival or recurrence patterns was demonstrated.

U2 - 10.1136/ijgc-2018-000023

DO - 10.1136/ijgc-2018-000023

M3 - Journal article

C2 - 30640686

AN - SCOPUS:85060019463

VL - 29

SP - 68

EP - 76

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

SN - 1048-891X

IS - 1

ER -

ID: 236317539