Forskning ved Københavns Universitet - Københavns Universitet

Forside

The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Olga Castañer
  • Montserrat Fitó
  • M Carmen López-Sabater
  • Poulsen, Henrik Enghusen
  • Kristiina Nyyssönen
  • Helmut Schröder
  • Jukka T Salonen
  • Karina De la Torre-Carbot
  • Hans-Franz Zunft
  • Rafael De la Torre
  • Hans Bäumler
  • Antonio V Gaddi
  • Guillermo T Saez
  • Marta Tomás
  • Maria-Isabel Covas
  • for the EUROLIVE Study Group
  • Helmut Schröder
BACKGROUND & AIM: Oxidized LDL (oxLDL) is a highly immunogenic particle that plays a key role in the development of atherosclerosis. Some data suggest a protective role of OxLDL autoantibodies (OLAB) in atherosclerosis. Our aim was to assess the effect of olive oil polyphenols on the immunogenicity of oxLDL to autoantibody generation. METHODS: In a crossover, controlled trial, 200 healthy men were randomly assigned to 3-week sequences of 25 mL/day of 3 olive oils with high (366 mg/kg), medium (164 mg/kg), and low (2.7 mg/kg) phenolic content. RESULTS: Plasma OLAB concentration was inversely associated with oxLDL (p 
OriginalsprogEngelsk
TidsskriftClinical Nutrition
Vol/bind30
Udgave nummer4
Sider (fra-til)490-493
ISSN0261-5614
DOI
StatusUdgivet - 2 mar. 2011

ID: 34091061