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The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

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  • Shigehiko Ogoh
  • Kohei Sato
  • James P Fisher
  • Thomas Seifert
  • Morten Overgaard
  • Niels H Secher
Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (S(c) O(2) ) and increases middle cerebral artery mean blood velocity (MCA V(mean) ), suggesting a-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.
OriginalsprogEngelsk
TidsskriftClinical Physiology and Functional Imaging
Vol/bind31
Udgave nummer6
Sider (fra-til)445-51
Antal sider7
ISSN1475-0961
DOI
StatusUdgivet - 2011

ID: 40193709