Forskning ved Københavns Universitet - Københavns Universitet


The genome of the model beetle and pest Tribolium castaneum.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Tribolium Genome Sequencing Consortium, Project leader, Stephen Richards, Principal investigators, Richard A Gibbs, George M Weinstock, White paper, Susan J Brown, Robin Denell, Richard W Beeman, Richard Gibbs, Analysis leaders, Richard W Beeman, Susan J Brown, Gregor Bucher, Markus Friedrich, Cornelis J P Grimmelikhuijzen, Martin Klingler, Marce Lorenzen, Stephen Richards & 56 andre Siegfried Roth, Reinhard Schröder, Diethard Tautz, Evgeny M Zdobnov, DNA sequence and global analysis: DNA sequencing, Donna Muzny, Richard A Gibbs, George M Weinstock, Tony Attaway, Stephanie Bell, Christian J Buhay, Mimi N Chandrabose, Dean Chavez, Kerstin P Clerk-Blankenburg, Andrew Cree, Marvin Dao, Clay Davis, Joseph Chacko, Huyen Dinh, Shannon Dugan-Rocha, Gerald Fowler, Toni T Garner, Jeffrey Garnes, Andreas Gnirke, Alica Hawes, Judith Hernandez, Sandra Hines, Michael Holder, Jennifer Hume, Shalini N Jhangiani, Vandita Joshi, Ziad Mohid Khan, EST sequencing, genome assembly, G+C content, repetitive DNA, transposons and telomeres, gene prediction and consensus gene set, global gene content analysis, Developmental processes and signalling pathways, Pest biology, senses, Medea and RNAi: ligand gated ion channels, oxidative phosphorylation, P450 genes, chitin and cuticular proteins, digestive proteinases, immunity, neurohormones and GPCRs, Cornelis J P Grimmelikhuijzen, Frank Hauser, Giuseppe Cazzamali, Michael Williamson, neuropeptide processing enzymes, opsins, odorant receptors and gustatory receptors, odorant binding and chemosensory proteins, Medea, systemic RNAi

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.
Udgivelsesdato: e-pub.2008-Apr-24
Sider (fra-til)949-955
Antal sider7
StatusUdgivet - 2008

ID: 3337610