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The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • N Stefan
  • B Vozarova
  • A Del Parigi
  • V Ossowski
  • D B Thompson
  • R L Hanson
  • E Ravussin
  • P A Tataranni
  • Barbora de Courten
Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P
OriginalsprogEngelsk
TidsskriftInternational Journal of Obesity
Vol/bind26
Udgave nummer12
Sider (fra-til)1629-32
Antal sider4
ISSN0307-0565
DOI
StatusUdgivet - 1 dec. 2002

ID: 33926888