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The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism

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Standard

The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. / Stefan, N; Vozarova, B; Del Parigi, A; Ossowski, V; Thompson, D B; Hanson, R L; Ravussin, E; Tataranni, P A; de Courten, Barbora.

I: International Journal of Obesity, Bind 26, Nr. 12, 01.12.2002, s. 1629-32.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Stefan, N, Vozarova, B, Del Parigi, A, Ossowski, V, Thompson, DB, Hanson, RL, Ravussin, E, Tataranni, PA & de Courten, B 2002, 'The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism', International Journal of Obesity, bind 26, nr. 12, s. 1629-32. https://doi.org/10.1038/sj.ijo.0802161

APA

Stefan, N., Vozarova, B., Del Parigi, A., Ossowski, V., Thompson, D. B., Hanson, R. L., ... de Courten, B. (2002). The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. International Journal of Obesity, 26(12), 1629-32. https://doi.org/10.1038/sj.ijo.0802161

Vancouver

Stefan N, Vozarova B, Del Parigi A, Ossowski V, Thompson DB, Hanson RL o.a. The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. International Journal of Obesity. 2002 dec 1;26(12):1629-32. https://doi.org/10.1038/sj.ijo.0802161

Author

Stefan, N ; Vozarova, B ; Del Parigi, A ; Ossowski, V ; Thompson, D B ; Hanson, R L ; Ravussin, E ; Tataranni, P A ; de Courten, Barbora. / The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. I: International Journal of Obesity. 2002 ; Bind 26, Nr. 12. s. 1629-32.

Bibtex

@article{fa48bad4ecdb4ef6a32971b42b0c5c8a,
title = "The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism",
abstract = "Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P",
keywords = "Adipocytes, Adult, Cell Size, Energy Metabolism, Female, Genotype, Homozygote, Humans, Indians, North American, Lipid Metabolism, Male, Motor Activity, Polymorphism, Genetic, Receptors, Cell Surface, Receptors, Leptin",
author = "N Stefan and B Vozarova and {Del Parigi}, A and V Ossowski and Thompson, {D B} and Hanson, {R L} and E Ravussin and Tataranni, {P A} and {de Courten}, Barbora",
year = "2002",
month = "12",
day = "1",
doi = "10.1038/sj.ijo.0802161",
language = "English",
volume = "26",
pages = "1629--32",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",
number = "12",

}

RIS

TY - JOUR

T1 - The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism

AU - Stefan, N

AU - Vozarova, B

AU - Del Parigi, A

AU - Ossowski, V

AU - Thompson, D B

AU - Hanson, R L

AU - Ravussin, E

AU - Tataranni, P A

AU - de Courten, Barbora

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P

AB - Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P

KW - Adipocytes

KW - Adult

KW - Cell Size

KW - Energy Metabolism

KW - Female

KW - Genotype

KW - Homozygote

KW - Humans

KW - Indians, North American

KW - Lipid Metabolism

KW - Male

KW - Motor Activity

KW - Polymorphism, Genetic

KW - Receptors, Cell Surface

KW - Receptors, Leptin

U2 - 10.1038/sj.ijo.0802161

DO - 10.1038/sj.ijo.0802161

M3 - Journal article

C2 - 12461680

VL - 26

SP - 1629

EP - 1632

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 12

ER -

ID: 33926888